【91339108】ACE2/Apelin信号对高血压血管外膜炎症、氧化应激及重构的调控作用与机制国家自然基金项目

ACE2/Apelin信号对高血压血管外膜炎症、氧化应激及重构的调控作用与机制

项目批准号： 91339108

批准年份： 2013

学科分类： H0213.血压调节异常与高血压病

项目负责人：钟久昌

资助类别：重大研究计划

负责人职称：研究员

依托单位：上海交通大学

资助金额： 85万元

关键词：炎症;氧化应激;血管重构;血管紧张素转换酶2;高血压病

起止时间： 2014-01-01到2016-12-31

中英文摘要
结题摘要
结题报告
项目成果
项目参与人

查看更多信息请先登录或注册

序号	标题	类型	作者
1	重组血管紧张素转换酶2对高血压小鼠肾脏Nephrin信号及结构损伤的影响。	期刊论文	张振洲\|宋蓓\|高平进\|钟久昌\|
2	Crucial Role of miR-433 in Regulating Cardiac Fibrosis.	期刊论文	Xu, Bin\|Zhong, Jiuchang\|Xiao, Junjie\|Li, Xinli\|
3	ACE2/Ang-(1-7) signaling and vascular remodeling	期刊论文	Chen LaiJiang\|Zhong JiuChang\|Gao PingJin\|Oudit, Gavin Y.\|
4	Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.	期刊论文	Wang, Wang\|McKinnie, Shaun M K\|Vederas, John C\|Oudit, Gavin Y\|
5	重组血管紧张素转换酶2 对ApoE 基因缺陷小鼠肾脏caspase 信号及细胞凋亡的影响	期刊论文	金海燕\|陈来江\|宋蓓\|钟久昌\|
6	Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling	期刊论文	Oudit, Gavin Y.\|Gao, Ping-Jin\|Zhu, Ding-Liang\|Zhong, Jiu-Chang\|
7	Angiotensin-converting enzyme 2 ameliorates renal fibrosis by blocking the activation of mTOR/ERK signaling in apolipoprotein E-deficient mice	期刊论文	Jin, Hai-Yan\|Chang, Qing\|Zhu, Ding-Liang\|Zhong, Jiu-Chang\|
8	从2014年美国成人高血压治疗指南推荐看肾素-血管紧张素-醛固酮系统阻断剂在高血压病防治中的地位。	期刊论文	钟久昌\|
9	GW26-e2401 Upregulated levels of miR-122-5p and let-7b-3p in aortas of spontaneously hypertensive rats in association with downregulated levels of Apelin, miR-1-3p, miR-376b-3p and miR-298-5p (Abstract)J Am Coll Cardiol, 2015,66(16Supple): C77.	会议论文	Xu R\|Xu YL\|Gao PJ\|Zhu DL\|
10	Angiotensin-Converting Enzyme 2 Is a Critical Determinant of Angiotensin II-Induced Loss of Vascular Smooth Muscle Cells and Adverse Vascular Remodeling	期刊论文	McMurtry, Michael Sean\|Davidge, Sandra T.\|Kassiri, Zamaneh\|Oudit, Gavin Y.\|
11	ACE2/Apelin信号与动脉粥样硬化	期刊论文	张振洲\|宋蓓\|钟久昌\|
12	Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure.	期刊论文	Patel, Vaibhav B\|Zhong, Jiu-Chang\|Grant, Maria B\|Oudit, Gavin Y\|
13	OS 36-07 Treatment with apelin-13prevents pressure overload-induced aortic adventitial remodeling and fibrosisin hypertensive rats with TAC. J Hypertens. 2016;34(Suppl 1):e403-404.	会议论文	Song B\|Chang Q\|Gao PJ\|Wang JG\|
14	Impact of ACE2 gene polymorphism on antihypertensive efficacy of ACE inhibitors	期刊论文	Liu GZ\|He M\|Jin LJ\|Yu HM\|
15	Inhibition of miR-155 Protects Against LPS-induced Cardiac Dysfunction and Apoptosis in Mice.	期刊论文	Zhong, Jiuchang\|Li, Xinli\|Kong, Xiangqing\|Xiao, Junjie\|
16	AT1受体阻断剂对小鼠海马脑源性神经营养因子信号的影响	期刊论文	张振洲\|林国珍\|高平进\|钟久昌\|
17	Association between circulating levels of ACE2-Ang-(1-7)-MAS axis and ACE2 gene polymorphisms in hypertensive patients	期刊论文	Zhang, Caojin\|Lin, Shuguang\|Wu, Shulin\|Yu, Huimin\|
18	miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury	期刊论文	Sluijter JPG\|Li X\|Rosenzweig A\|Xiao J\|
19	微小RNA和血管紧张素转换酶2/血管紧张素(1~7)信号与高血压	期刊论文	徐冉\|钟久昌\|
20	The Relationship Between Nocturnal Blood Pressure and Hemorrhagic Stroke in Chinese Hypertensive Patients	期刊论文	Wei, Xin\|Wang, Baisong\|Zhong, Jiuchang\|Fu, Yi\|
21	The ACE2/Apelin Signaling, MicroRNAs, and Hypertension.	期刊论文	Xu, Ran\|Yu, Hui-Min\|Chang, Qing\|Zhong, Jiu-Chang\|
22	血管紧张素转换酶2基因与高血压心血管炎症。	期刊论文	陈来江\|钟久昌\|
23	GW25-e1669: Apelin treatment enhances ACE2 expression and attenuates angiotensin II-mediated aortic fibrosis in apolipoprotein E-deficient mice. J Am Coll Cardiol, 2014;64(16S): C6-7	会议论文	Zhu DL\|Gao PJ\|Oudit GY\|Zhong JC\|
24	Ascending aortic adventitial remodeling and fibrosisare ameliorated with Apelin-13 in rats after TAC via suppression of themiRNA-122 and LGR4-β-catenin signaling	期刊论文	Song, Bei\|Chen, Dong-Rui\|Zhu, Ding-Liang\|Zhong, Jiu-Chang\|

查看更多信息请先登录或注册

再问科研

趋势报告

经验分享