乙酰胆碱酯酶新基序AChE7-20非酶活性依赖的海马神经元毒性调控机制

81573415
2015
H3501.神经精神药物药理
陈红专
面上项目
教授
上海交通大学
72万元
乙酰胆碱酯酶;阿尔茨海默病;海马神经元;β淀粉样蛋白;α7烟碱乙酰胆碱受体
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
重置
序号 标题 类型 作者
1 AChE Inhibition-based Multi-target-directed Ligands, a Novel Pharmacological Approach for the Symptomatic and Disease-modifying Therapy of Alzheimer's Disease 期刊论文 Wang Yu;Wang Hao;Chen Hong zhuan
2 阿尔兹海默病靶标新药的基础和临床研究以及早期干预策略 奖励 陈红专
3 Design, synthesis, biological evaluation, and molecular modeling studies of chalcone-rivastigmine hybrids as cholinesterase inhibitors 期刊论文 Ling Wang;Yu Wang;Yiguang Tian;Jinling Shang;Xiaoou Sun;Hongzhuan Chen;Hao Wang;Wen Tan
4 Direct SUMOylation of M1 muscarinic acetylcholine receptor increases its ligand-binding affinity and signal transduction 期刊论文 Xu Jianrong;Tan Panpan;Li Hui;Cui Yongyao;Qiu Yu;Wang Hao;Zhang Xuan;Li Juan;Zhu Liang;Zhou Wei;Chen Hongzhuan
5 Bis(9)-(-)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice 期刊论文 Shi Yuhuan;Huang Wanying;Wang Yu;Zhang Rui;Hou Lina;Xu Jianrong;Qiu Zhuibai;Xie Qiong;Chen Hongzhuan;Zhang Yongfang;Wang Hao
6 胆碱系统药理学的调控新机制以及靶标新药的研究 奖励 陈红专;崔永耀;陆伟跃;胡雅儿;何祥火;魏冬青;肖世富;陆阳;谢琼;徐见容
7 M1 muscarinic receptors facilitate hippocampus-dependent cognitive flexibility via modulating GluA2 subunit of AMPA receptors 期刊论文 Xiong Cai Hong;Liu Ming Gang;Zhao Lan Xue;Chen Mu Wen;Tang Ling;Yan Ying Hui;Chen Hong Zhuan;Qiu Yu
8 Effects of BIS-MEP on Reversing Amyloid Plaque Deposition and Spatial Learning and Memory Impairments in a Mouse Model of beta-Amyloid Peptide- and Ibotenic Acid-Induced Alzheimer's Disease 期刊论文 Wang Yu;Xia Jia;Shen Mengjun;Zhou Yifan;Wu Zhe;Shi Yuhuan;Xu Jianrong;Hou Lina;Zhang Rui;Qiu Zhuibai;Xie Qiong;Chen Hongzhuan;Zhang Yongfang;Wang Hao
9 M1 Muscarinic Receptor Activation Rescues beta-Amyloid-Induced Cognitive Impairment through AMPA Receptor GluA1 Subunit 期刊论文 Zhao Lan Xue;Chen Mu Wen;Qian Yue;Yang Qian Hao;Ge Yan Hui;Chen Hong Zhuan;Qiu Yu
10 M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt 期刊论文 Zhao Lan Xue;Ge Yan Hui;Li Jia Bing;Xiong Cai Hong;Law Ping Yee;Xu Jian Rong;Qiu Yu;Chen Hong Zhuan
11 一种基于抗体的乙酰胆碱酯酶芯片固定方法及其在小分子抑制剂研发中的应用 专利 王昊;徐见容;陈红专;胡梦薇;赵兰雪;侯丽娜;王宇;李苗苗;黄婉莹
查看更多信息请先登录或注册

趋势报告

经验分享