SENPs选择性抑制剂的设计、合成、以及抗肿瘤活性研究

81573264
2015
H3401.合成药物化学
周虎臣
面上项目
教授
上海交通大学
60万元
类泛素化通路;抗肿瘤活性;选择性抑制剂;SENP
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Design and synthesis of -phenoxy-N-sulfonylphenyl acetamides as Trypanosoma brucei leucyl-tRNA synthetase inhibitors. 期刊论文 Weixiang Xin;Zezhong Li;Qing Wang;Jin Du;Mingyan Zhu;Huchen Zhou
2 Development and evaluation of a highly reliable assay for SUMO-specificprotease inhibitors 期刊论文 Wenjuan Xie;Zhongli Wang;Jiong Zhang;Lie Wang;Yaxue Zhao;Huchen Zhou
3 Identification of SENP1 inhibitors through in silico screening and rational drug design 期刊论文 Zhao Yaxue;Wang Zhongli;Zhang Jianchen;Zhou Huchen
4 Progress in the Discovery of Small Molecule Modulators of DeSUMOylation 期刊论文 Chen Shiyao;Dong Duoling;Xin Weixiang;Zhou Huchen
5 Development of a highly reliable assay for ubiquitin-specific protease 2 inhibitors 期刊论文 Zhongli Wang;Wenjuan Xie;Mingyan Zhu;Huchen Zhou
6 Cdc42 Signaling Pathway Inhibition as a Therapeutic Target in Ras-Related Cancers 期刊论文 Aguilar Byron J.;Zhou Huchen;Lu Qun
7 Synthesis of biologically active boron-containing compounds. 期刊论文 Fei Yang;Mingyan Zhu;Jiong Zhang;Huchen Zhou
8 Inhibition of Cdc42-intersectin interaction by small molecule ZCL367 impedes cancer cell cycle progression, proliferation, migration, and tumor growth 期刊论文 Aguilar Byron J.;Zhao Yaxue;Zhou Huchen;Huo Shouquan;Chen Yan-Hua;Lu Qun
9 C89 Induces Autophagy of Female Germline Stem Cells via Inhibition of the PI3K-Akt Pathway In Vitro 期刊论文 Li Xinyue;Hu Xiaopeng;Tian Geng G.;Cheng Ping;Li Zezhong;Zhu Mingyan;Zhou Huchen;Wu Ji
10 Design, Synthesis, and Structure-Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents 期刊论文 Zhang Jiong;Zhang Jinyi;Hao Guiyun;Xin Weixiang;Yang Fei;Zhu Mingyan;Zhou Huchen
11 Azobenzene-based small molecular photoswitches for protein modulation. 期刊论文 Mingyan Zhu;Huchen Zhou
12 GAS5/miR-21 Axis as a Potential Target to Rescue ZCL-082-Induced Autophagy of Female Germline Stem Cells In Vitro 期刊论文 Li Bo;Hu Xiaopeng;Yang Yanzhou;Zhu Mingyan;Zhang Jiong;Wang Yanrong;Pei Xiuying;Zhou Huchen;Wu Ji
13 Chalcone-benzoxaborole hybrids as novel anticancer agents 期刊论文 Jiong Zhang;Fei Yang;Zhitao Qiao;Mingyan Zhu;Huchen Zhou
14 一种苯并硼唑7位脂肪酸的衍生物及其制备与用途 专利 周虎臣;张煚;朱明彦;叶龙;冯怡卿
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