表观遗传元件超级增强子在Hedgehog通路失调肿瘤的发病和治疗中的作用和机制
81572761
2015
H1805.肿瘤表观遗传
唐玉杰
面上项目
研究员
上海交通大学
70万元
BET;bromodomain抑制分子;针对SMO抑制分子的抗药性;表观遗传调控;Hedgehog通路失调肿瘤;超级增强子
2016-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Enhanced efficacy of histone deacetylase inhibitor combined with bromodomain inhibitor in glioblastoma | 期刊论文 | Meng Wei;Wang Baocheng;Mao Weiwei;Wang Jiajia;Zhao Yang;Li Qifeng;Zhang Chenran;Tang Yujie;Ma Jie |
| 2 | Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma | 期刊论文 | Nagaraja Surya;Vitanza Nicholas A.;Woo Pamelyn J.;Taylor Kathryn R.;Liu Fang;Zhang Lei;Li Meng;Meng Wei;Ponnuswami Anitha;Sun Wenchao;Ma Jie;Hulleman Esther;Swigut Tomek;Wysocka Joanna;Tang Yujie;Monje Michelle |
| 3 | CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo | 期刊论文 | Meng Wei;Wang Jiajia;Wang Baocheng;Liu Fang;Li Meng;Zhao Yang;Zhang Chenran;Li Qifeng;Chen Juxiang;Zhang Liye;Tang Yujie;Ma Jie |
| 4 | CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists | 期刊论文 | Liu Fang;Jiang Wenyan;Sui Yi;Meng Wei;Hou Linjun;Li Tiantian;Li Meng;Zhang Lei;Mo Jialin;Wang Jiajia;Zhao Yang;Zhang Liye;Ma Jie;Tang Yujie |
| 5 | THZ1 reveals CDK7-dependent transcriptional addictions in pancreatic cancer. | 期刊论文 | Lu Ping;Geng Jing;Zhang Lei;Wang Yu;Niu Ningning;Fang Yuan;Liu Fang;Shi Juanjuan;Zhang Zhi Gang;Sun Yong Wei;Wang Li Wei;Tang Yujie;Xue Jing |
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