【81272568】两相释药降低乳腺癌细胞耐药靶向给药系统的研究国家自然基金项目

两相释药降低乳腺癌细胞耐药靶向给药系统的研究

项目批准号： 81272568

批准年份： 2012

学科分类： H1821.肿瘤治疗抵抗

项目负责人：段友容

资助类别：面上项目

负责人职称：研究员

依托单位：上海交通大学

资助金额： 70万元

关键词：两相释药;多药耐药;靶向;乳腺癌;递送系统

起止时间： 2013-01-01到2016-12-31

中英文摘要
结题摘要
结题报告
项目成果
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序号	标题	类型	作者
1	Enhanced therapeutic effect of Adriamycin on multidrug resistant breast cancer by the ABCG2-siRNA loaded polymeric nanoparticles assisted with ultrasound	期刊论文	Zhang, Xiangyu\|Xu, Yuanyuan\|Duan, Yourong\|Du, Lianfang\|
2	Degradation behavior and biosafety studies of the mPEG-PLGA-PLL copolymer	期刊论文	He, Zelai\|Sun, Ying\|Cao, Jun\|Duan, Yourong\|
3	Inhibition Effect of Exercise Assisted Mitoxantrone Hydrochloride Loaded mPEG-PLGA-PLL-cRGD Nanoparticles in Hepal-6 Tumor	期刊论文	Sun, Qiufen\|Wang, Bingwu\|Duan, Yourong\|Zhang, Jun\|
4	The synergic antitumor effects of paclitaxel and temozolomide co-loaded in mPEG-PLGA nanoparticles on glioblastoma cells	期刊论文	Sun, Ying\|Teng, Yanwei\|Wang, Yi\|Duan, Yourong\|
5	Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma	期刊论文	Wang, Qi\|Sun, Ying\|Zhang, Zhirong\|Duan, Yourong\|
6	Antitumor Efficacy of Paclitaxel-Loaded Polylactide/Poly(ethylene glycol) Nanoparticles Combination with Exercise in Tumor-Bearing Mice	期刊论文	Liu, Peifeng\|Ji, Qin\|Qi, Jie\|Duan, Yourong\|
7	Uptake Mechanism and Endosomal Fate of Drug-Phospholipid Lipid Nanoparticles in Subcutaneous and In Situ Hepatoma	期刊论文	Gong, Tao\|Sun, Xun\|Duan, Yourong\|Zhang, Zhirong\|
8	Targeted delivery of biodegradable nanoparticles with ultrasound-targeted microbubble destruction-mediated hVEGF-siRNA transfection in human PC-3 cells in vitro	期刊论文	Jin, Li-Fang\|Du, Lian-Fang\|Liu, Pei-Feng\|Duan, You-Rong\|
9	Fast Detection of Alpha-Fetoprotein-L3 Using Lens Culinaris Agglutinin Immobilized Gold Nanoparticles	期刊论文	Liu, Dejun\|Liu, Changhong\|Sun, Yongwei\|Duan, Yourong\|
10	Enhanced delivery of PEAL nanoparticles with ultrasound targeted microbubble destruction mediated siRNA transfection in human MCF-7/S and MCF-7/ADR cells in vitro	期刊论文	Xing, Jinfang\|Du, Lianfang\|Gong, Tao\|Duan, Yourong\|
11	Preparation, blood coagulation and cell compatibility evaluation of chitosan-graft-polylactide copolymers	期刊论文	Gong, Tao\|Li, Suming\|Duan, Yourong\|Zhang, Zhirong\|
12	F127/Calcium phosphate hybrid nanoparticles: a promising vector for improving siRNA delivery and gene silencing	期刊论文	Liu, Peifeng\|Wang, Qi\|Han, Baosan\|Duan, Yourong\|
13	siRNA Delivery Mediated by Copolymer Nanoparticles, Phospholipid Stabilized Sulphur Hexafluoride Microbubbles and Ultrasound	期刊论文	Du, Jing\|Li, Fan\|Du, Lianfang\|Duan, Yourong\|
14	Low toxicity and long circulation time of Polyampholyte-coated magnetic nanoparticles for blood pool contrast agents	期刊论文	Xu, Yuanyuan\|Lin, Jiang\|Duan, Yourong\|Gu, Hongchen\|
15	The biocompatibility evaluation of mPEG-PLGA-PLL copolymer and different LA/GA ratio effects for biocompatibility	期刊论文	Zhu, Mingjie\|Gu, Malin\|Wang, Yi\|Duan, Yourong\|
16	A New PAMPA Model Proposed on the Basis of a Synthetic Phospholipid Membrane	期刊论文	Sun, Ying\|Shen, Ming\|Li, He\|Duan, Yourong\|
17	Calcium Phosphate/Octadecyl-Quatemized Carboxymethyl Chitosan Nanoparticles: An Efficient and Promising Carrier for Gene Transfection	期刊论文	Li, Xiaoyu\|Liang, Xiaofei\|Wan, Zhiyong\|Duan, Yourong\|
18	Preparation and properties of biocompatible PS-PEG/calcium phosphate nanospheres	期刊论文	Zhu, Mingjie\|Sun, Xun\|Zhang, Zhirong\|Duan, Yourong\|
19	Specific cell targeting with APRPG conjugated PEG-PLGA nanoparticles for treating ovarian cancer	期刊论文	Zhou, Jinhua\|Wang, Wenwen\|Qiu, Lihua\|Di, Wen\|
20	Toxicity and therapy of cisplatin-loaded EGF modified mPEG-PLGA-PLL nanoparticles for SKOV3 cancer in mice	期刊论文	Zhu, Mingjie\|Gu, Liying\|Di, Wen\|Duan, Yourong\|
21	Intracellular trafficking and cellular uptake mechanism of mPEG-PLGA-PLL and mPEG-PLGA-PLL-Gal nanoparticles for targeted delivery to hepatomas	期刊论文	Wang, Qi\|Sun, Ying\|Li, He\|Duan, Yourong\|
22	Contrast-enhanced susceptibility weighted imaging with ultrasmall superparamagnetic iron oxide improves the detection of tumor vascularity in a hepatocellular carcinoma nude mouse model	期刊论文	Han, Zhi-hong\|Fu, Cai-xia\|Hu, Feng-lin\|Gu, Hong-chen\|
23	Study of SiRNA-loaded PS-mPEG/CaP nanospheres on lung cancer	期刊论文	Qin, Liubin\|Sun, Ying\|Shen, Ming\|Duan, Yourong\|
24	Preparation of a Thermosensitive Gel Composed of a mPEG-PLGA-PLL-cRGD Nanodrug Delivery System for Pancreatic Tumor Therapy	期刊论文	Xu, Yuan-Yuan\|Sun, Ying\|Han, Bao-Shan\|Duan, You-Rong\|
25	Curcumin-Conjugated NaYF4:Yb3+, Er3+ Nanoparticles for Photodynamic Therapy Based on Near-Infrared Light	期刊论文	Sun, Ying\|Gao, Pei\|Li, He\|Duan, Yourong\|
26	EGF-modified mPEG-PLGA-PLL nanoparticle for delivering doxorubicin combined with Bcl-2 siRNA as a potential treatment strategy for lung cancer	期刊论文	Hao Fu\|Yiwei Fang\|Baoshan Han\|Yourong Duan\|
27	Biocompatible and colloidally stabilized mPEG-PE/calcium phosphate hybrid nanoparticles loaded with siRNAs targeting tumors	期刊论文	Zhang, Qinghong\|Li, He\|Li, Yaogang\|Duan, Yourong\|

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