心血管疾病的表观遗传机制研究
81422002
2014
H02.循环系统
陈厚早
优秀青年科学基金项目
研究员
中国医学科学院基础医学研究所
100万元
表观修饰酶；组蛋白去乙酰化酶；血管性疾病；心肌肥厚；心力衰竭
2015-01至2017-12
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Mitochondrial Sirtuins in cardiometabolic diseases | 期刊论文 | Tang Xiaoqiang();Chen Xiao-Feng;Chen Hou-Zao();Liu De-Pei() |
| 2 | PON基因簇在制备用于治疗动脉粥样硬化的药物中的用途 | 专利 | 刘德培; 折志刚; 郑伟; 韦玉生; 陈厚早 |
| 3 | Calorie restriction protects against experimental abdominal aortic aneurysms in mice. | 期刊论文 | Liu Yue;Wang Ting-Ting;Zhang Ran;Fu Wen-Yan;Wang Xu;Wang Fang;Gao Peng;Ding Yang-Nan;Xie Yan;Hao De-Long;Chen Hou-Zao;Liu De-Pei |
| 4 | 血管细胞衰老在腹主动脉瘤发病中作用 | 会议论文 | 陈厚早 |
| 5 | Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. | 期刊论文 | Luo YX; Tang X; An XZ; Xie XM; Chen XF; Zhao X; Hao DL; Chen HZ; Liu DP |
| 6 | SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy | 期刊论文 | Xiaoqiang Tang;Xiao-Feng Chen;Nan-Yu Wang;Xiao-Man Wang;Shu-Ting Liang;Wei Zheng;Yun-Biao Lu;Xiang Zhao;De-Long Hao;Zhu-Qin Zhang;Ming-Hui Zou;De-Pei Liu;Hou-Zao Chen |
| 7 | The Paraoxonase Gene Cluster Protects Against Abdominal Aortic Aneurysm Formation. | 期刊论文 | Yan, Yun-Fei; Pei, Jian-Fei; Zhang, Ran; Wang, Fang; Gao, Peng; Zhang, Zhu-Qin; Wang, Ting-Ting; Zhang, Yang; She, Zhi-Gang; Chen, Hou-Zao; Liu, De-Pei |
| 8 | Critical roles of SIRTuins in age-related cardiac hypertrophy | 会议论文 | 陈厚早 |
| 9 | Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice | 期刊论文 | Pei, Jian-Fei; Yan, Yun-Fei; Tang, Xiaoqiang; Zhang, Yang; Cui, Shen-Shen; Zhang, Zhu-Qin; Chen, Hou-Zao; Liu, De-Pei |
| 10 | Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice. | 期刊论文 | Zhang ZQ; Ren SC; Tan Y; Li ZZ; Tang X; Wang TT; Hao DL; Zhao X; Chen HZ; Liu DP |
| 11 | Epigenetic regulation in cell senescence | 期刊论文 | Cheng LQ;Zhang ZQ;Chen HZ;Liu DP |
| 12 | The Four Layers of Aging | 期刊论文 | Ran Zhang|Hou-Zao Chen|De-Pei Liu| |
| 13 | 三羟基黄酮在制备用于预防和治疗腹主动脉瘤的药物中的用途 | 专利 | 刘德培; 陈厚早; 王放 |
| 14 | Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm | 期刊论文 | Chen, Hou-Zao; Wang, Fang; Gao, Peng; Pei, Jian-Fei; Liu, Yue; Xu, Ting-Ting; Tang, Xiaoqiang; Fu, Wen-Yan; Lu, Jie; Yan, Yun-Fei; Wang, Xiao-Man; Han, Lei; Zhang, Zhu-Qin; Zhang, Ran; Zou, Ming-Hui; Liu, De-Pei |
| 15 | SIRT1 deacetylates the cardiac transcription factor Nkx2.5 and inhibits its transcriptional activity | 期刊论文 | Tang, Xiaoqiang; Ma, Han; Han, Lei; Zheng, Wei; Lu, Yun-Biao; Chen, Xiao-Feng; Liang, Shu-Ting; Wei, Gong-Hong; Zhang, Zhu-Qin; Chen, Hou-Zao; Liu, De-Pei |
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