老年痴呆症的细胞与分子机制
81225008
2012
H0912.神经退行性变及相关疾病
张云武
国家杰出青年科学基金
教授
厦门大学
200万元
老年痴呆症;APP代谢;beta-分泌酶BACE1;分子机制;蛋白相互作用
2013-01至2016-12
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation | 期刊论文 | Zheng Honghua;Liu Chia-Chen;Atagi Yuka;Chen Xiao-Fen;Jia Lin;Yang Longyu;He Wencan;Zhang Xilin;Kang Silvia S.;Rosenberry Terrone L.;Fryer John D.;Zhang Yun-Wu;Xu Huaxi;Bu Guojun |
| 2 | Appoptosin interactswith mitochondrial outer-membrane fusion proteins and regulates mitochondrialmorphology | 期刊论文 | Huaxi Xu|Huaxi Xu|Yun-wu Zhang|Yun-wu Zhang| |
| 3 | APP Regulates NGF Receptor Trafficking and NGF-Mediated Neuronal Differentiation and Survival | 期刊论文 | Zhang Yun-Wu;Chen Yaomin;Liu Yun;Zhao Yingjun;Liao Francesca-Fang;Xu Huaxi |
| 4 | Polyphenols isolated from leaves of Vitis thunbergii var. taiwaniana regulate APP related pathway. | 期刊论文 | Hu Jin;Lin Ting;Xu Junyue;Ding Rong;Wang Guanghui;Shen Ruichi;Zhang Yun-Wu;Chen Haifeng |
| 5 | Sorting Nexin 27 Regulates A beta Production through Modulating gamma-Secretase Activity | 期刊论文 | Wang Xin;Huang Timothy;Zhao Yingjun;Zheng Qiuyang;Thompson Robert C.;Bu Guojun;Zhang Yun-wu;Hong Wanjin;Xu Huaxi |
| 6 | Ferritin light chain interacts with PEN-2 and affects gamma-secretase activity | 期刊论文 | Li Xinxin;Liu Yiqian;Zheng Qiuyang;Yao Guorui;Cheng Peng;Bu Guojun;Xu Huaxi;Zhang Yun-Wu |
| 7 | Vps35 regulates cell surface recycling and signaling of dopamine receptor D1 | 期刊论文 | Ma Q|Ma Q|Zhang YW|Zhang YW| |
| 8 | Insufficient ER-stress response causes selective mouse cerebellar granule cell degeneration resembling that seen in congenital disorders of glycosylation | 期刊论文 | Sun Liangwu;Zhao Yingjun;Zhou Kun;Freeze Hudson H.;Zhang Yun-wu;Xu Huaxi |
| 9 | RPS23RG1 reduces Abeta oligomer-induced synaptic and cognitive deficits. | 期刊论文 | Yan Li();Chen Yaomin();Li Wubo();Huang Xiumei;Badie Hedieh;Jian Fan;Huang Timothy;Zhao Yingjun;Cohen Stanley N;Li Limin;Zhang Yun-Wu;Luo Huanmin;Tu Shichun;Xu Huaxi() |
| 10 | The neuron-specific protein TMEM59L mediates oxidative stress-induced cell death | 期刊论文 | Zheng Qiuyang;Zheng Xiaoyuan;Zhang Lishan;Luo Hong;Qian Lingzhi;Fu Xing;Liu Yiqian;Gao Yuehong;Niu Mengxi;Meng Jian;Zhang Muxian;Bu Guojun;Xu Huaxi;Zhang Yun-Wu |
| 11 | Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis | 期刊论文 | Zhao Yingjun;Tseng I-Chu;Heyser Charles J.;Rockenstein Edward;Mante Michael;Adame Anthony;Zheng Qiuyang;Huang Timothy;Wang Xin;Arslan Pharhad E.;Chakrabarty Paramita;Wu Chengbiao;Bu Guojun;Mobley William C.;Zhang Yun-wu;St George-Hyslop Peter;Masliah Eliezer;Fraser Paul;Xu Huaxi |
| 12 | The role of copper and the copper-related protein CUTA in mediating APP processing and A beta generation | 期刊论文 | Hou Ping;Liu Guiying;Zhao Yingjun;Shi Zhun;Zheng Qiuyang;Bu Guojun;Xu Huaxi;Zhang Yun wu |
| 13 | Protective role of miR-23b-3p in kainic acid-induced seizure | 期刊论文 | Zhan Lianbo;Yao Yi;Fu Huajun;Li Zhenghui;Wang Fengpeng;Zhang Xiaobin;He Wencan;Zheng Weihong;Zhang Yunwu;Zheng Honghua |
| 14 | M1 muscarinic acetylcholine receptor in Alzheimer's disease | 期刊论文 | Xu, Huaxi|Xu, Huaxi|Zhang, Yun-Wu|Zhang, Yun-Wu| |
| 15 | SNX15 Regulates Cell Surface Recycling of APP and Abeta Generation. | 期刊论文 | Feng Tuancheng;Niu Mengmeng;Ji Chengxiang;Gao Yuehong;Wen Jing;Bu Guojun;Xu Huaxi;Zhang Yun-Wu |
| 16 | The gamma-secretase complex: from structure to function | 期刊论文 | Zhang Xian;Li Yanfang;Xu Huaxi;Zhang Yun-wu |
| 17 | Trafficking regulation of proteins in Alzheimer's disease | 期刊论文 | Xu, Huaxi|Xu, Huaxi|Zhang, Yun-wu|Zhang, Yun-wu| |
| 18 | A novel presenilin 1 mutation (F388L) identified in a Chinese family with early-onset Alzheimer's disease | 期刊论文 | Rong Zhouyi|Xiao Naian|Ma Qilin|Zhang Yun-wu| |
| 19 | miR-219 protects against seizure in the kainic acid model of epilepsy | 期刊论文 | Zheng Honghua;Tang Rong;Yao Yi;Ji Zhilin;Cao Yuanyuan;Liu Zhaoji;Peng Feng;Wang Wenjie;Can Dan;Bu Guojun;Xu Huaxi;Xing Huiqin;Zhang Yun-wu;Zheng Weihong |
| 20 | The Resveratrol Trimer Miyabenol C Inhibits beta-Secretase Activity and beta-Amyloid Generation | 期刊论文 | Hu Jin;Lin Ting;Gao Yuehong;Xu Junyue;Jiang Chao;Wang Guanghui;Bu Guojun;Xu Huaxi;Chen Haifeng;Zhang Yun-wu |
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