线粒体突变和人类疾病

30925021
2009
H0809.白血病
姚永刚
国家杰出青年科学基金
研究员
中国科学院昆明动物研究所
200万元
mtDNA;进化医学;单细胞分析;遗传多样性
2010-01至2013-12
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Mutation p.G83R in the transthyretin gene is associated with hereditary vitreous amyloidosis in Han Chinese families 期刊论文 Zhang A-Mei;Wang Hui;Sun Peng;Hu Qiu-Xiang;He Yuqing;Yao Yong-Gang
2 Evaluating risk loci for schizophrenia distilled from genome-wide association studies in Han Chinese from central China 期刊论文 Ma Liang;Tang Jinsong;Wang Dong;Zhang Wen;Liu Weiqing;Wang Dong;Liu Xiao-Hong;Gong Wei;Yao Yong-Gang;Chen Xiaogang
3 Complete mitochondrial DNA genome sequence variation of Chinese families with mutation m.3635G > A and Leber hereditary optic neuropathy 期刊论文 Bi, Rui|Zhang, A-Mei|Jia, Xiaoyun|Zhang, Qingjiong|Yao, Yong-Gang|
4 Screening for mutation R882 in the DNMT3A gene in Chinese patients with hematological disease 期刊论文 Li Yunlong;Zhang Deng-Feng;Zhang Shi-Wen;Zeng Yun;Yao Yong-Gang
5 Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny 期刊论文 Bi Rui;Li Wen-Liang;Chen Ming-Qing;Zhu Zhu;Yao Yong-Gang
6 Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China 期刊论文 Wang Dong;Feng Jia-Qi;Li Yu-Ye;Zhang Deng-Feng;Li Xiao-An;Li Qing-Wei;Yao Yong-Gang
7 No association between the SNPs (rs3749446 and rs1402000) in the PARL gene and LHON in Chinese patients with m.11778G > A 期刊论文 Zhang, A-Mei|Jia, Xiaoyun|Zhang, Qingjiong|Yao, Yong-Gang|
8 Mitochondrial DNA Sequence Variation and Haplogroup Distribution in Chinese Patients with LHON and m.14484T > C 期刊论文 Yu, Dandan|Jia, Xiaoyun|Zhang, A-Mei|Li, Shiqiang|Zou, Yang|Zhang, Qingjiong|Yao, Yong-Gang|
9 The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations 期刊论文 Zou Yang;Jia Xiao-yun;Zhang A-Mei;Wang Wen-Zhi;Li Shi-qiang;Guo Xiang-ming;Kong Qing-Peng;Zhang Qing-jiong;Yao Yong-Gang
10 Is Mitochondrial tRNA(phe) Variant m.593T > C a Synergistically Pathogenic Mutation in Chinese LHON Families with m. 11778G > A? 期刊论文 Yao, Yong-Gang|Bandelt, Hans-Jürgen|Jia, Xiaoyun|Zhang, Wen|Li, Shiqiang|Yu, Dandan|Wang, Dong|Zhuang, Xin-Ying|Zhang, Qingjiong|
11 Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background 期刊论文 Yao Yong-Gang;Kajigaya Sachiko;Feng Xingmin;Samsel Leigh;McCoy Jr. J. Philip;Torelli Giuseppe;Young Neal S.
12 Apparent mtDNA sequence heterogeneity in single human blood CD34+ cells is markedly affected by storage and transport 期刊论文 Yao, Yong-Gang|Kajigaya, Sachiko|Samsel, Leigh|McCoy Jr., J.Philip|Torelli, Giuseppe|Young, Neal S.|
13 Trends in new leprosy case detection over 57 years (1952-2008) in Yuxi, Yunnan Province of Southwest China 期刊论文 Li Yu-Ye;Li Xiao-An;He Li;Wang Dong;Chen Wen-Ying;Chen Liang;Lu Jian-Bo;Yao Yong-Gang
14 MitoTool: A web server for the analysis and retrieval of human mitochondrial DNA sequence variations 期刊论文 Fan Long;Yao Yong-Gang
15 Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese 期刊论文 Zhang Wen;Chen Xiaogang;Gong Wei;Tang Jinsong;Tan Liwen;Guo Hao;Yao Yong-Gang
16 Mitochondrial DNA mutation m.10680G > A is associated with Leber hereditary optic neuropathy in Chinese patients 期刊论文 Zhang, A-Mei|Jia, Xiaoyun|Guo, Xiangming|Zhang, Qingjiong|Yao, Yong-Gang|
17 Molecular characterization of six Chinese families with m.3460G > A and Leber hereditary optic neuropathy 期刊论文 Yu, Dandan|Jia, Xiaoyun|Zhang, A-Mei|Guo, Xiangming|Zhang, Ya-Ping|Zhang, Qingjiong|Yao, Yong-Gang|
18 mtDNA Data Mining in GenBank Needs Surveying 期刊论文 Yao, Yong-Gang|Salas, Antonio|Logan, Ian|Bandelt, Hans-Jürgen|
19 Genetic variants of complement genes Ficolin-2, Mannose-binding lectin and Complement factor H are associated with leprosy in Han Chinese from Southwest China 期刊论文 Zhang Deng-Feng;Huang Xian-Qiong;Wang Dong;Li Yu-Ye;Yao Yong-Gang
20 Deciphering the Signature of Selective Constraints on Cancerous Mitochondrial Genome 期刊论文 Liu Jia;Wang Li-Dong;Sun Yan-Bo;Li En-Min;Xu Li-Yan;Zhang Ya-Ping;Yao Yong-Gang;Kong Qing-Peng
21 No association of the LRRK2 genetic variants with Alzheimer’s disease in Han Chinese individuals. 期刊论文 Li, Tao|Zhao, Liansheng|Zhang, Chen|Lu, Weihong|Feng, Jia-Qi|Wang, Yingcheng|Ni, Jianliang|Zhang, Jiangtao|Li, Guo-Dong|
22 IDH1 and IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia but rare in other types of hematological disorders. 期刊论文 Zou, Yang|Zeng, Yun|Zhang, Deng-Feng|Zou, Shan-Hua|Cheng, Yun-Feng|Yao, Yong-Gang|
23 An update to MitoTool: Using a new scoring system for faster mtDNA haplogroup determination 期刊论文 Fan Long;Yao Yong-Gang
24 Identification of mutation c. 632G > A (p.G211D) in the ATP2A2 gene and genotype-phenotype correlation in a large Chinese family with Darier';s disease 期刊论文 Lu, Feng-Yan|Xu, Ling|Yin, Xun-Guo|Wan, Ping|Zhang, Xiao-De|Chen, Wei-Wen|Ding, Shao-Ping|Yao, Yong-Gang|
25 Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin';s lymphoma in Chinese patients 期刊论文 Xiao, Mei-Sheng|Zhang, Deng-Feng|Zeng, Yun|Cheng, Yun-Feng|Yao, Yong-Gang|
26 Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin 期刊论文 Feng Yue-Mei|Jia Yun-Fang|Su Lin-Yan|Wang Dong|Lv Li|Xu Lin|Yao Yong-Gang|
27 Genetic Polymorphisms of the CASP8 Gene Promoter May Not Be Associated with Colorectal Cancer in Han Chinese from Southwest China 期刊论文 Xiao Mei Sheng;Chang Le;Li Wen Liang;Du Yong Sheng;Pan Yue;Zhang Deng Feng;Wen Yu;Luo Juan;Li Xiao Yan;Yao Yong Gang
28 Screening the three LHON primary mutations in the general Chinese population by using an optimized multiplex allele-specific PCR 期刊论文 Bi Rui;Zhang A-Mei;Yu Dandan;Chen Diana;Yao Yong-Gang
29 The case for the continuing use of the revised Cambridge Reference Sequence (rCRS) and the standardization ofnotation in human mitochondrial DNA studies 期刊论文 Bandelt Hans-Jürgen;Kloss-Brandstätter Anita;Richards Martin B;Yao Yong-Gang;Logan Ian
30 The Acquisition of an Inheritable 50-bp Deletion in the Human mtDNA Control Region Does Not Affect the mtDNA Copy Number in Peripheral Blood Cells 期刊论文 Bi Rui;Zhang A-Mei;Zhang Wen;Kong Qing-Peng;Wu Bei-Ling;Yang Xiao-Hong;Wang Dong;Zou Yang;Zhang Ya-Ping;Yao Yong-Gang
31 Mitochondrial DNA Haplogroup Background Affects LHON, but Not Suspected LHON, in Chinese Patients 期刊论文 A-Mei Zhang;Xiaoyun Jia;Rui Bi;Antonio Salas;Shiqiang Li;Xueshan Xiao;Panfeng Wang;Xiangming Guo;Qing-Peng Kong;Qingjiong Zhang;Yong-Gang Yao
32 Leber's hereditary optic neuropathy 期刊论文 Bi, Rui|Zhang, A-Mei|Yao, Yong-Gang|
33 Large-Scale mtDNA Screening Reveals a Surprising Matrilineal Complexity in East Asia and Its Implications to the Peopling of the Region 期刊论文 Kong Qing-Peng;Sun Chang;Wang Hua-Wei;Zhao Mian;Wang Wen-ZHi;Zhong Li;Hao Xiao-Dan;Pan Hui;Wang Sha-Yan;Cheng Yao-Ting;Zhu Chun-Lin;Wu Shi-Fang;Liu Li-Na;Jin Jie-Qiong;Yao Yong-Gang;Zhang Ya-Pin
34 Presence of mutation m.14484T>C in a Chinese family with maternally inherited essential hypertension but no expression of LHON 期刊论文 Yao, Yong-Gang|Zhuang, Xin-Ying|Zhang, A-Mei|Zhang, Wen|Yuan, Yong|Guo, Li|Yu, Dandan|Liu, Juan|Yang, Da-Kuan|
35 Mitochondrial DNA Copy Number, but Not Haplogroup, Confers a Genetic Susceptibility to Leprosy in Han Chinese from Southwest China 期刊论文 Wang Dong;Su Ling-Yan;Zhang A-Mei;Li Yu-Ye;Li Xiao-An;Chen Ling-Ling;Long Heng;Yao Yong-Gang
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