Long noncoding RNA MEG3 regulates LATS2 by promoting the ubiquitination of EZH2 and inhibits proliferation and invasion in gallbladder cancer

Longyang Jin;Qiang Cai;Shouhua Wang;Shuqing Wang;Tanmoy Mondal;Jiandong Wang;Zhiwei Quan

期刊论文

10.1038/s41419-018-1064-1

SCIE

Cell Death and Disease

9#10

2018/10/3

-

#

Gallbladder cancer (GBC) is the most common type of biliary tract cancer worldwide. Long noncoding RNAs (lncRNAs).play essential roles in physiological and pathological development. LncRNA MEG3, a tumor suppressor, has been.reported to play important roles in some cancers, but the role of MEG3 in GBC remains largely unknown. The purpose.of the present study was to explore the role of MEG3 in proliferation and invasion and the potential molecular.mechanism in GBC. We found that MEG3 was downregulated in GBC tissues and cells, and low expression of MEG3.was correlated with poor prognostic outcomes in patients. Overexpression of MEG3 inhibited GBC cell proliferation.and invasion, induced cell apoptosis and decreased tumorigenicity in nude mice. Moreover, we found that MEG3 was.associated with EZH2 and attenuated EZH2 by promoting its ubiquitination. Furthermore, MEG3 executed its functions.via EZH2 to regulate the downstream target gene LATS2. Taken together, these findings suggest that MEG3 is an.effective target for GBC therapy and may facilitate the development of lncRNA-directed diagnostics and therapeutics.against GBC.

抑制LncRNA-VSTM4介导的异常自噬在逆转胆囊癌化疗耐药中的机制研究