【91132303】情感和记忆调控的抑制性神经环路机制国家自然基金项目

情感和记忆调控的抑制性神经环路机制

项目批准号： 91132303

批准年份： 2011

学科分类： H0902.意识障碍与认知功能障碍

项目负责人：徐天乐

资助类别：重大研究计划

负责人职称：教授

依托单位：上海交通大学

资助金额： 300万元

关键词：情感和记忆;紧张性抑制;γ-氨基丁酸受体;甘氨酸受体;抑制性神经环路

起止时间： 2012-01-01到2015-12-31

中英文摘要
结题摘要
结题报告
项目成果
项目参与人

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序号	标题	类型	作者
1	2-Guanidine-4-methylquinazoline acts as a novel competitive antagonist of A type g-aminobutyric acid receptors	期刊论文	Xiao X\|Zhu MX\|Xu TL\|
2	2015上海市领军人才	奖励
3	Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction	会议论文	Zhu MX\|Zhu MX\|Xu TL\|Xu TL\|
4	Alpha-asarone from Acorus gramineus alleviates epilepsy by modulating A-Type GABA receptors	期刊论文	Wang, Li\|Xu, Tian-Le\|Wu, Dazheng\|Li, Yong\|
5	14-3-3 tau Promotes Surface Expression of Cav2.2 (alpha 1B) Ca2+ Channels	期刊论文	Hou, Zhaoyuan\|Zhou, Aiwu\|Zhou, Yi\|Li, Yong\|
6	Acid-sensing ion channels: a novel therapeutic target for pain and anxiety	期刊论文	Li WG\|Xu TL\|
7	GABA Transporter-1 Deficiency Confers Schizophrenia-Like Behavioral Phenotypes	期刊论文	Chen, Zhong\|Fei, Jian\|Gong, Neng\|Xu, Tian-Le\|
8	Acid-Sensing Ion Channels: A Novel Therapeutic Target for Pain and Anxiety	期刊论文	Wei-Guang Li\|Tian-Le Xu\|
9	Role of the potassium chloride cotransporter isoform 2-mediated spinal chloride homeostasisin a rat model of visceral hypersensitivity	期刊论文	Sun J\|Li WG\|Xu TL\|Yuan YZ*\|
10	Molecular mechanism of constitutive endocytosis of acid-sensing ion channel 1a and its protective function in acidosis-induced neuronal death	期刊论文	Jiang W\|Zhu MX\|Li Y\|Xu TL\|
11	GABA Transporter-1 Deficiency Confers Schizophrenia-Like Behavioral Phenotypes	期刊论文	Chen, Zhong\|Fei, Jian\|Gong, Neng\|Xu, Tian-Le\|
12	Highly conserved salt bridge stabilizes rigid signal patch at extracellular loop critical for surface expression of acid-sensing ion channels	期刊论文	Wang J\|Zhu MX\|Wang R\|Xu TL\|
13	Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction	会议论文
14	Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligand sensing domain of ASIC3 channel	期刊论文	Zeng WZ\|Peng Z\|Zhu MX\|Xu TL\|
15	Electrophysiological characterization of methyleugenol: a novel agonist of GABA(A) receptors.	期刊论文	Xu, Tian-Le\|Ge, Wei-Hong\|Li, Wei-Guang\|Li, Fei\|
16	Subunit-Specific Inhibition of Glycine Receptors by Curcumol	期刊论文	Michael X. Zhu\|Tian-Le Xu\|Dazheng Wu\|Yong Li\|
17	Curcumol from Rhizoma Curcumae suppresses epileptic seizure by facilitation of GABA(A) receptors.	期刊论文	Xu, Tian-Le\|Ge, Wei-Hong\|Li, Wei-Guang\|Li, Fei\|
18	Emerging approaches to probing ion channel structure and function	期刊论文	Wei-Guang Li\|Tian-Le Xu\|
19	Temporal dynamics ofanxiety phenotypes in a dental pulp injury model	期刊论文	Xu TL\|Li F\|Su J\|Li WG\|
20	Sequential Posttranslational Modifications Regulate PKC Degradation	期刊论文	Huang C\|Zhou A\|Zhou Y\|Li Y\|
21	Intracellular ASIC1a regulates mitochondrial permeability transition-dependent neuronal death.	期刊论文	Tang D\|Dong XP\|Zhu MX\|Xu TL\|
22	PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity	期刊论文	Yu H\|Zhu MX\|Chen ZY\|Xu TL\|
23	Modulation of GluK2a Subunit-containing Kainate Receptors by 14-3-3 Proteins	期刊论文	Wang Y\|Wu Y\|Zhou Y\|Li Y\|
24	Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation	期刊论文	Zhou, Tong\|Xu, Tian-Le\|Cheng, Jinke\|Li, Yong\|
25	Targeting acid-sensing ion channels for the treatment of neurological diseases	会议论文
26	Subunit-specificinhibition of glycine receptors by curcumol	期刊论文	Zhu MX\|Xu TL\|Wu D\|Li Y\|
27	神经科学研究生创新人才培养的实践和思考	会议论文
28	ASIC3 mediates itch sensation in response to coincident stimulation by acid and nonproton ligand	期刊论文	Wang X\|Zhu MX\|Cheng XY\|Xu TL\|

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