蛋白激酶p38alpha MAPK调控巨噬细胞极化在特发性肺纤维化中的作用机制研究与新型药物靶标
81573438
2015
H3504.抗炎与免疫药物药理
钱峰
面上项目
教授
上海交通大学
60万元
巨噬细胞;特发性肺纤维化;p38丝裂原活化蛋白激酶;免疫调控;趋化因子
2016-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Akt1 regulates pulmonary fibrosis via modulating IL-13 expression in macrophages | 期刊论文 | Nie Yunjuan;Hu Yudong;Yu Kaikai;Zhang Dan;Shi Yinze;Li Yaolin;Sun Lei;Qian Feng |
| 2 | Protostemonine attenuates alternatively activated macrophage and DRA-induced asthmatic inflammation | 期刊论文 | Song Yunduan;Wu Yaxian;Li Xiaozong;Shen Yao;Ding Yunhe;Zhu Hongbo;Liu Fangfang;Yu Kaikai;Sun Lei;Qian Feng |
| 3 | MK2 mediates macrophage activation and acute lung injury by regulating let-7e miRNA | 期刊论文 | Wu Yaxian;He Huiqiong;Ding Yunhe;Liu Sirui;Zhang Depeng;Wang Jun;Jiang Hongchao;Zhang Dan;Sun Lei;Ye Richard D;Qian Feng |
| 4 | Isoalantolactone suppresses LPS-induced inflammation by inhibiting TRAF6 ubiquitination and alleviates acute lung injury | 期刊论文 | Ding Yun he;Song Yun duan;Wu Ya xian;He Hui qiong;Yu Tian hong;Hu Yu dong;Zhang De peng;Jiang Hong chao;Yu Kai kai;Li Xiao zong;Sun Lei;Qian Feng |
| 5 | MLN4924 protects against interleukin-17A-induced pulmonary inflammation by disrupting ACT1-mediated signaling | 期刊论文 | Hao Rui;Song Yunduan;Li Runsheng;Wu Yaxian;Yang Xinyi;Li Xiaozong;Qian Feng;Ye Richard D;Sun Lei |
| 6 | Protostemonine effectively attenuates lipopolysaccharide-induced acute lung injury in mice | 期刊论文 | Wu Ya-xian;He Hui-qiong;Nie Yun-juan;Ding Yun-he;Sun Lei;Qian Feng |
| 7 | Emodin alleviates alternatively activated macrophage and asthmatic airway inflammation in a murine asthma model | 期刊论文 | Song Yun duan;Li Xiao zong;Wu Ya xian;Shen Yao;Liu Fang fang;Gao Pei pei;Sun Lei;Qian Feng |
| 8 | Lanatoside C inhibits cell proliferation and induces apoptosis through attenuating Wnt/beta-catenin/c-Myc signaling pathway in human gastric cancer cell | 期刊论文 | Hu Yudong;Yu Kaikai;Wang Gang;Zhang Depeng;Shi Chaoji;Ding Yunhe;Hong Duo;Zhang Dan;He Huiqiong;Sun Lei;Zheng Jun-Nian;Sun Shuyang;Qian Feng |
| 9 | AKT2 Regulates Pulmonary Inflammation and Fibrosis via Modulating Macrophage Activation | 期刊论文 | Nie Yunjuan;Sun Lei;Wu Yaxian;Yang Yaoyao;Wang Jun;He Huiqiong;Hu Yudong;Chang Yanhua;Liang Qing;Zhu Jianwei;Ye Richard D;Christman John W;Qian Feng |
| 10 | p38α MAP kinase promotes asthmatic inflammation through modulation of alternatively activated macrophages. | 期刊论文 | Linian Huang;Lei Sun;Liming Liu;Huihui Zhang;Zhong-bo Liang;Yan Rui;Junfeng Hu;Yong Zhang;John W. Christman;Feng Qian |
| 11 | Nedd8 modification of Cullin-5 regulates lipopolysaccharide-induced acute lung injury | 期刊论文 | Zhu Ziyan;Sun Lei;Hao Rui;Jiang Hongchao;Qian Feng;Ye Richard D |
| 12 | Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination | 期刊论文 | Zhang Depeng;Li Xiaozong;Hu Yudong;Jiang Hongchao;Wu Yaxian;Ding Yunhe;Yu Kaikai;He Huiqiong;Xu Jingsong;Sun Lei;Qian Feng |
| 13 | 耐甲氧西林金黄色葡萄球菌诱导巨噬细胞焦亡的机制研究 | 期刊论文 | 蔡妩扬;刘思蕊;杜华钰;钱峰;孙磊 |
| 14 | A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver schemia/Reperfusion Injury | 期刊论文 | Sun Lei();Wu Qiong;Nie Yunjuan;Cheng Ni;Wang Rui;Wang Gang;Zhang Dan;He Huiqiong;Ye Richard D;Qian Feng() |
| 15 | HMGB1研究进展 | 期刊论文 | 蔡妩扬;蒋骏航;钱峰 |
| 16 | Costunolide alleviates HKSA-induced acute lung injury via inhibition of macrophage activation | 期刊论文 | Chen Yun tian;Du Yao;Zhao Bo;Gan Li xing;Yu Kai kai;Sun Lei;Wang Jian;Qian Feng |
| 17 | 原百部碱在制备抗哮喘药物中的用途 | 专利 | 钱峰;何慧琼;吴亚先 |
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