异菝葜皂苷元治疗阿尔茨海默病的组蛋白乙酰化调控机制研究

81573401
2015
H3501.神经精神药物药理
张永芳
面上项目
副研究员
上海交通大学
54万元
组蛋白乙酰化;异菝葜皂苷元;阿尔茨海默病;组蛋白脱乙酰化酶
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 异菝葜皂苷元在阿尔茨海默病中的作用及其机制 会议论文 张永芳
2 miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease 期刊论文 Hu Yong-Bo;Zhang Yong-Fang;Wang Hao;Ren Ru-Jing;Cui Hai-Lun;Huang Wan-Ying;Cheng Qi;Chen Hong-Zhuan;Wang Gang
3 Bis(9)-(-)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice 期刊论文 Shi Yuhuan;Huang Wanying;Wang Yu;Zhang Rui;Hou Lina;Xu Jianrong;Qiu Zhuibai;Xie Qiong;Chen Hongzhuan;Zhang Yongfang;Wang Hao
4 新型乙酰胆碱酯酶抑制剂双配基-(-)-美普他酚改善APP/PS1转基因小鼠学习记忆功能的机制 期刊论文 史玉欢;黄婉莹;侯丽娜;张瑞;张永芳;陈红专;王昊
5 Effects of BIS-MEP on Reversing Amyloid Plaque Deposition and Spatial Learning and Memory Impairments in a Mouse Model of beta-Amyloid Peptide- and Ibotenic Acid-Induced Alzheimer's Disease 期刊论文 Wang Yu;Xia Jia;Shen Mengjun;Zhou Yifan;Wu Zhe;Shi Yuhuan;Xu Jianrong;Hou Lina;Zhang Rui;Qiu Zhuibai;Xie Qiong;Chen Hongzhuan;Zhang Yongfang;Wang Hao
6 ERK/CREB信号通路在异菝葜皂苷元促进Aβ损伤SH-SY5Y细胞BDNF表达中的作用 期刊论文 张瑞;夏志明;孙小余;李加梅;张永芳;胡雅儿
7 The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer's disease 期刊论文 Yang Shuang-shuang;Zhang Rui;Wang Gang;Zhang Yong-fang
8 知母皂苷元对H_2O_2损伤SH-SY5Y细胞中脑源性神经营养因子的调控及机制研究 期刊论文 杨双双;高天行;何萱;张瑞;张永芳
9 Peripheral Blood MicroRNA Expression Profiles in Alzheimer's Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism. 期刊论文 Ren rujin;zhang yongfang;Dammer EB;Zhou Y;Wang LL;Liu XH;Feng BL;Wang gang
10 Catalpol protects synaptic proteins from beta-amyloid induced neuron injury and improves cognitive functions in aged rats 期刊论文 Xia Zhiming;Wang Fengfei;Zhou Shuang;Zhang Rui;Wang Fushun;Huang Jason H;Wu Erxi;Zhang Yongfang;Hu Yaer
11 知母活性成分治疗神经退行性疾病的作用机制 会议论文 何萱;张永芳
12 Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid—Lesioned Parkinson’s Disease Models 期刊论文 Xuan He;Shuangshuang Yang;Rui Zhang;Lina Hou;Jianrong Xu;Yaer Hu;Rang Xu;Hao Wang;Yongfang Zhang
13 Rho-associated coiled-coil kinase 1 activation mediates amyloid precursor protein site-specific Ser655 phosphorylation and triggers amyloid pathology. 期刊论文 Hu Yong-Bo;Ren Ru-Jing;Zhang Yong-Fang;Huang Yue;Cui Hai-Lun;Ma Chao;Qiu Wen-Ying;Wang Hao;Cui Pei-Jing;Chen Hong-Zhuan;Wang Gang
14 microRNA-425及其类似物作为阿尔茨海默病治疗的核苷酸药物的应用 专利 王昊;张永芳
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