重组高密度脂蛋白纳米递药系统的脑内清除机制研究
81573382
2015
H3409.药物材料
高小玲
面上项目
研究员
上海交通大学
70万元
清除;脑靶向;纳米递药系统;血脑屏障;胶质淋巴系统
2016-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Biomimetic ApoE-Reconstituted High Density Lipoprotein Nanocarrier for Blood-Brain Barrier Penetration and Amyloid Beta-Targeting Drug Delivery | 期刊论文 | Song Qingxiang;Song Huahua;Xu Jianrong;Huang Jialin;Hu Meng;Gu Xiao;Chen Juan;Zheng Gang;Chen Hongzhuan;Gao Xiaoling |
| 2 | Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis | 期刊论文 | Huang J.-L.;Jiang G.;Song Q.-X.;Gu X.;Hu M.;Wang X.-L.;Song H.-H.;Chen L.-P.;Lin Y.-Y.;Jiang D.;Chen J.;Feng J.-F.;Qiu Y.-M.;Jiang J.-Y.;Jiang X.-G.;Chen H.-Z.;Gao X.-L. |
| 3 | 阿尔兹海默病防治药物的基础和临床药理学研究 | 奖励 | 陈红专;肖世富;陈生弟;李华芳;胡雅儿;陆阳;高小玲;邱瑜;周薇;王涛;王刚;王昊;徐见容;沈一峰;冯雪梅 |
| 4 | Metformin and Docosahexaenoic Acid Hybrid Micelles for Premetastatic Niche Modulation and Tumor Metastasis Suppression | 期刊论文 | Jiang Tianze;Chen Liang;Huang Yukun;Wang Jiahao;Xu Minjun;Zhou Songlei;Gu Xiao;Chen Yu;Liang Kaifan;Pei Yuanyuan;Song Qingxiang;Liu Shanshan;Ma Fenfen;Lu Huiping;Gao Xiaoling;Chen Jun |
| 5 | 阿尔茨海默病防治药物的基础和临床药理学研究 | 奖励 | 高小玲 |
| 6 | Harnessing Exosomes for the Development of Brain Drug Delivery Systems | 期刊论文 | Zheng Mengna;Huang Meng;Ma Xinyi;Chen Hongzhuan;Gao Xiaoling |
| 7 | Lipid-coated calcium phosphate nanoparticle and beyond: a versatile platform for drug delivery | 期刊论文 | Huang Jia-Lin;Chen Hong-Zhuan;Gao Xiao-Ling |
| 8 | “万人计划”青年拔尖人才 | 奖励 | 高小玲 |
| 9 | 曙光计划 | 奖励 | 高小玲 |
| 10 | Sequential Targeting TGF-beta Signaling and KRAS Mutation Increases Therapeutic Efficacy in Pancreatic Cancer | 期刊论文 | Pei Yuanyuan;Chen Liang;Huang Yukun;Wang Jiahao;Feng Jingxian;Xu Minjun;Chen Yu;Song Qingxiang;Jiang Gan;Gu Xiao;Zhang Qian;Gao Xiaoling;Chen Jun |
| 11 | High-density lipoprotein-biomimetic nanocarriers for glioblastoma-targeting delivery: the effect of shape | 期刊论文 | Huang Jia-Lin;Jiang Gan;Song Qing-Xiang;Gu Xiao;Song Hua-Hua;Wang Xiao-Lin;Jiang Di;Kang Ting;Feng Xing-Ye;Jiang Xin-Guo;Chen Hong-Zhuan;Gao Xiao-Ling |
| 12 | The application of nanoparticles for neuroprotection in acute ischemic stroke | 期刊论文 | Chen Lepei;Gao Xiaoling |
| 13 | 阿尔茨海默病靶标新药的基础和临床研究以及早期干预策略 | 奖励 | 高小玲 |
| 14 | Neovasculature and circulating tumor cells dual-targeting nanoparticles for the treatment of the highly-invasive breast cancer | 期刊论文 | Yao Jianhui;Feng Jingxian;Gao Xiaoling;Wei Dan;Kang Ting;Zhu Qianqian;Jiang Tianze;Wei Xunbin;Chen Jun |
| 15 | Necroptotic cancer cells-mimicry nanovaccine boosts anti-tumor immunity with tailored immune-stimulatory modality | 期刊论文 | Kang Ting;Huang Yukun;Zhu Qianqian;Cheng Hao;Pei Yuanyuan;Feng Jingxian;Xu Minjun;Jiang Gan;Song Qingxiang;Jiang Tianze;Chen Hongzhuan;Gao Xiaoling;Chen Jun |
| 16 | 阿尔茨海默病靶标新药的基础和临床研究以及早期干预策略 | 奖励 | 陈红专;肖世富;王刚;高小玲;陈生弟;胡雅儿;魏冬青;陈钧;王涛;谢琼;徐见容;仇缀百;陆阳;张奇志;李华芳 |
| 17 | α倒捻子素与载α倒捻子素纳米制剂促进小胶质细胞摄取Aβ的作用比较 | 期刊论文 | 王大元;宋华华;胡朦;李娟;谷晓;高小玲 |
| 18 | GM1-Modified Lipoprotein-like Nanoparticle: Multifunctional Nanoplatform for the Combination Therapy of Alzheimer's Disease | 期刊论文 | Huang Meng;Hu Meng;Song Qingxiang;Song Huahua;Huang Jialin;Gu Xiao;Wang Xiaolin;Chen Jun;Kang Ting;Feng Xingye;Jiang Di;Zheng Gang;Chen Hongzhuan;Gao Xiaoling |
| 19 | 2018 Nano Research Young Innovator Award in NanoBiotech | 奖励 | 高小玲 |
| 20 | The shape effect of reconstituted high-density lipoprotein nanocarriers on brain delivery and A beta clearance | 期刊论文 | Song Huahua;Ma Xinyi;Xu Jianrong;Song Qingxiang;Hu Meng;Gu Xiao;Zhang Qian;Hou Lina;Chen Lepei;Huang Yukun;Yu Ping;Wang Dayuan;Jiang Gan;Huang Meng;Chen Jun;Chen Hongzhuan;Gao Xiaoling |
| 21 | Nanoparticles Coated with Neutrophil Membranes Can Effectively Treat Cancer Metastasis | 期刊论文 | Kang Ting;Zhu Qianqian;Wei Dan;Feng Jingxian;Yao Jianhui;Jiang Tianze;Song Qingxiang;Wei Xunbin;Chen Hongzhuan;Gao Xiaoling;Chen Jun |
| 22 | 胶质母细胞瘤的免疫治疗研究进展 | 期刊论文 | 吕英琪;陈曜星;卫晨萱;江淦;高小玲 |
| 23 | Nanoformulated alpha-mangostin ameliorates Alzheimer's disease neuropathology by elevating LDLR expression and accelerating amyloid-beta clearance | 期刊论文 | Lei Yao;Xiao Gu;Qingxiang Song;Xiaolin Wang;Meng Huang;Meng Hu;Lina Hou;Ting Kang;Jun Chen;Hongzhuan Chen;Xiaoling Gao |
| 24 | Noninvasive monitoring of nanoparticle clearance and aggregation in blood circulation by in vivo flow cytometry | 期刊论文 | Wei Dan;Pang Kai;Song Qingxiang;Suo Yuanzhen;He Hao;Weng Xiaofu;Gao Xiaoling;Wei Xunbin |
| 25 | Reconstituted high-density lipoproteins: novel biomimetic nanocarriers for drug delivery | 期刊论文 | Ma Xinyi;Song Qingxiang;Gao Xiaoling |
| 26 | 一种单唾液酸四己糖神经节苷脂修饰的重组脂蛋白及其应用 | 专利 | 高小玲;黄萌;陈红专;宋清香 |
| 27 | 一种靶向修复神经血管病变的纳米复合物及其制备与应用 | 专利 | 高小玲;宋清香;章倩;陈红专;江淦 |
| 28 | 一种包载固相内核的重组脂蛋白及其制备和应用 | 专利 | 高小玲;黄佳琳;江淦;宋清香;陈红专 |
| 29 | 呫酮类化合物及其衍生物在制备降血脂药物中的应用 | 专利 | 高小玲;胡朦;王小林;陈红专 |
| 30 | 一种单唾液酸四己糖神经节苷脂修饰的重组脂蛋白及其应用 | 专利 | 高小玲();黄萌;陈红专;宋清香 |
| 31 | 一种靶向多肽修饰的载药脂蛋白纳米递药系统及其制备和应用 | 专利 | 江淦;高小玲;陈欢;宋清香;陈红专 |
查看更多信息请先登录或注册
趋势报告
