GPRC5A基因杂合性缺失在肺癌发生中的作用机理和意义
81572759
2015
H1804.肿瘤遗传与进化
邓炯
面上项目
研究员
上海交通大学
60万元
肺肿瘤;动物模型;GPRCA;C05_气管;杂合性缺失;驱动突变;支气管
2016-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Iron-dependent CDK1 activity promotes lung carcinogenesis via activation of the GP130/STAT3 signaling pathway | 期刊论文 | Kuang Yanbin;Guo Wenzheng;Ling Jing;Xu Dongliang;Liao Yueling;Zhao Hui;Du Xiaohui;Wang Han;Xu Mingxin;Song Hongyong;Wang Tong;Jing Bo;Li Kaimi;Hu Min;Wu Wenjuan;Deng Jiong;Wang Qi |
| 2 | GPRC5A deficiency leads to dysregulated MDM2 via activated EGFR signaling for lung tumor development. | 期刊论文 | Song Hongyong;Sun Beibei;Liao Yueling;Xu Dongliang;Guo Wenzheng;Wang Tong;Jing Bo;Hu Min;Li Kaimi;Yao Feng;Deng Jiong |
| 3 | Nuclear survivin promoted by acetylation is associated with the aggressive phenotype of oral squamous cell carcinoma. | 期刊论文 | Liu Shuli;Shi Lei;Yang Xi;Ye Dongxia;Wang Tong;Dong Cunshan;Guo Wenzheng;Liao Yueling;Song Hongyong;Xu Dongliang;Hu Jingzhou;Zhang Zhiyuan;Deng Jiong |
| 4 | ALDH2 Repression Promotes Lung Tumor Progression via Accumulated Acetaldehyde and DNA Damage | 期刊论文 | Li Kaimi;Guo Wenzheng;Li Zhanming;Wang Yang;Sun Beibei;Xu Dongliang;Ling Jing;Song Hongyong;Liao Yueling;Wang Tong;Jing Bo;Hu Min;Kuang Yanbin;Wang Qi;Yao Fang;Sun Aijun;Zhu Liang;Wang Lishun;Deng Jiong |
| 5 | p53 suppression is essential for oncogenic SPAG5 upregulation in lung adenocarcinoma | 期刊论文 | Wang Tong;Li Kaimi;Song Hongyong;Xu Dongliang;Liao Yueling;Jing Bo;Guo Wenzheng;Hu Min;Kuang Yanbin;Sun Beibei;Ling Jing;Zhang Tuo;Xu Jianhua;Yao Feng;Deng Jiong |
| 6 | Dysregulated ENPP1 increases the malignancy of human lung cancer by inducing epithelial-mesenchyma transition phenotypes and stem cell features | 期刊论文 | Hu Min;Guo Wenzheng;Liao Yueling;Xu Dongliang;Sun Beibei;Song Hongyong;Wang Tong;Kuang Yanbin;Jing Bo;Li Kaimi;Ling Jing;Yao Feng;Deng Jiong |
| 7 | Stabilization of Slug by NF-kappa B is Essential for TNF-alpha -Induced Migration and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma Cells | 期刊论文 | Liu Shuli;Shi Lei;Wang Yang;Ye Dongxia;Ju Houyu;Ma Hailong;Yang Wenyi;Wan Yanan;Hu Jingzhou;Deng Jiong;Zhang Zhiyuan |
| 8 | High Vimentin Expression Associated with Lymph Node Metastasis and Predicated a Poor Prognosis in Oral Squamous Cell Carcinoma. | 期刊论文 | Liu Shuli;Liu Liu;Ye Weimin;Ye Dongxia;Wang Tong;Guo Wenzheng;Liao Yueling;Xu Dongliang;Song Hongyong;Zhang Ling;Zhu Hanguang;Deng Jiong;Zhang Zhiyuan |
| 9 | Interleukin-6/STAT3 Signaling Orchestrates Pre-metastatic Niche Formation and Immunosuppressive Trais in Lung | 期刊论文 | Bo Jing;Tong Wang;Beibei Sun;Jiong Deng |
| 10 | Stabilization of PTGES by deubiquitinase USP9X promotes metastatic features of lung cancer via PGE(2) signaling | 期刊论文 | Wang Tong;Jing Bo;Sun Beibei;Liao Yueling;Song Hongyong;Xu Dongliang;Guo Wenzheng;Li Kaimi;Hu Min;Liu Shuli;Ling Jing;Kuang Yanbin;Feng Yao;Zhou Binhua P;Deng Jiong |
| 11 | Repression of GPRC5A is associated with activated STAT3, which contributes to tumor progression of head and neck squamous cell carcinoma. | 期刊论文 | Liu Shuli;Ye Dongxia;Wang Tong;Guo Wenzheng;Song Hongyong;Liao Yueling;Xu Dongliang;Zhu Hanguang;Zhang Zhiyuan;Deng Jiong |
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