新型肿瘤抑制剂Compound 2靶向降解癌性蛋白EZH2作用及机制研究
81572646
2015
H1815.肿瘤靶向治疗
王旭
面上项目
副研究员
上海交通大学
57万元
口腔和口咽部肿瘤;藤黄精酸;表观遗传学
2016-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Elevated RET expression enhances EGFR activation and mediates EGFR inhibitor resistance in head and neck squamous cell carcinoma. | 期刊论文 | Lin Chengzhong;Lu Wei;Ren Zhenhu;Tang Yu;Zhang Chunye;Yang Rong;Chen Yiming;Cao Wei;Wang Lizhen;Wang Xu;Ji Tong |
| 2 | Cancer stem-like cell related protein CD166 degrades through E3 ubiquitin ligase CHIP in head and neck cancer | 期刊论文 | Xiao Meng;Yan Ming;Zhang Jianjun;Xu Qin;Qi Shengcai;Wang Xu;Chen Wantao |
| 3 | GDNF secreted by nerves enhances PD-L1 expression via JAK2-STAT1 signaling activation in HNSCC | 期刊论文 | Lin Chengzhong;Cao Wei;Ren Zhenhu;Tang Yu;Zhang Chunye;Yang Rong;Chen Yiming;Liu Zheqi;Peng Canbang;Wang Lizhen;Wang Xu;Ji Tong |
| 4 | A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. | 期刊论文 | Wang Xu;Cao Wei;Zhang Jianjun;Yan Ming;Xu Qin;Wu Xiangbing;Wan Lixin;Zhang Zhiyuan;Zhang Chenping;Qin Xing;Xiao Meng;Ye Dongxia;Liu Yuyang;Han Zeguang;Wang Shaomeng;Mao Li;Wei Wenyi;Chen Wantao |
| 5 | A 20(S)-protopanoxadiol derivative overcomes multi-drug resistance by antagonizing ATP-binding cassette subfamily B member 1 transporter function. | 期刊论文 | Chen Gang;Liu Junhua;Chen Wantao;Xu Qin;Xiao Meng;Hu Lihong;Mao Li;Wang Xu |
| 6 | 泛素E3连接酶CHIP在口腔鳞癌中介导GNA002引起EZH2泛素化降解的机制研究 | 会议论文 | 王晓宁;王旭;张建军;严明;徐骎;陈万涛 |
| 7 | 组蛋白去甲基化酶KDM6A抑制剂在制备肥胖症治疗药物的用途 | 专利 | 王旭;陈万涛;韦严 |
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