不同动物源性致病性钩端螺旋体遗传变异规律和致病差异的分子机制研究

81271793
2012
H2201.病原细菌与感染
郭晓奎
面上项目
教授
上海交通大学
60万元
致病差异;比较基因组学;动物宿主;遗传变异;致病性钩体
2013-01-01到2016-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Isolation and characterization of two novel plasmids from pathogenic Leptospira interrogans serogroup Canicola Serovar Canicola strain Gui44. 期刊论文 Wang, Yan-Zhuo|Qin, Jin-Hong|Zhu, Yong-Zhang|Guo, Xiao-Kui|
2 Identification of three extra-chromosomal replicons in Leptospira pathogenic strain and development of new shuttle vectors. 期刊论文 Liu, Boyu|Guo, Xiaokui|Zhao, Guoping|Qin, Jinhong|
3 Genetic and molecular biological characterization of two homologous cheR genes from Leptospira interrogans 期刊论文 Liu, Chang|Wang, Jin|Guo, Xiaokui|Zhao, Guo-Ping|
4 Whole genome sequencing revealed host adaptation-focused genomic plasticity of pathogenic Leptospira 期刊论文 Zhao, Guoping|Zheng, Huajun|Guo, Xiaokui|Wang, Junzhi|
5 Distribution of Plasmids in Distinct Leptospira Pathogenic Species. 期刊论文 Dong, Ke|Pal, Utpal|Guo, Xiaokui|Qin, Jinhong|
6 Molecular Typing of Pathogenic Leptospira Serogroup Icterohaemorrhagiae Strains Circulating in China during the Past 50 Years. 期刊论文 Chang, Yung-Fu|Guo, Xiaokui|Zhu, Yongzhang|Jiang, Xiugao|
7 Extracellular Proteome Analysis of Leptospira interrogans serovar Lai 期刊论文 Zhuang, Xuran|Zhu, Weinan|Guo, Xiaokui|Qin, Jinhong|
8 Carboxyfluorescein diacetate succinimidyl ester labeling method to study the interaction between Leptospira and macrophages. 期刊论文 Guo, Xiaokui|Zhu, Weinan|Zhang, Yan|He, Ping|
9 Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants. 期刊论文 Xia-Li Ding|Yung-Fu Chang|Xiao-Kui Guo|Yong-Zhang Zhu|
10 Characterization of a bifunctional enzyme with (p)ppGpp-hydrolase/synthase activity in Leptospira interrogans. 期刊论文 Zhang, Yan|Jiang, XuCheng|Guo, XiaoKui|Qin, JinHong|
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