Cbx4经SUMO化修饰增强HIF-1a转录活性的分子机制与肝癌发生发展

81430061
2014
H18.肿瘤学
陈国强
重点项目
教授
上海交通大学
320万元
染色盒蛋白4;低氧诱导因子1;活性化合物;C09_肝和肝内胆管肿瘤;SUMO化修饰
2015-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 A Novel Role for Pyruvate Kinase M2 as a Corepressor for P53 during the DNA Damage Response in Human Tumor Cells 期刊论文 Xia Li;Wang Xin-Ran;Wang Xiao-Ling;Liu Su-Hui;Ding Xiao-Wei;Chen Guo-Qiang;Lu Ying
2 Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial-mesenchymal transition of colon cancer 期刊论文 Xiong Zhong;Guo Meng;Yu Yun;Zhang Fei-Fei;Ge Meng-Kai;Chen Guo-Qiang;Shen Shao-Ming
3 AIF inhibits tumor metastasis by protecting PTEN from oxidation 期刊论文 Shen Shao-Ming;Guo Meng;Xiong Zhong;Yu Yun;Zhao Xu-Yun;Zhang Fei-Fei;Chen Guo-Qiang
4 Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells 期刊论文 Xia;Li;Qin;Kang;Wang;Xin-Ran;Wang;Xiao-Ling;Zhou;Ai-Wu;Chen;Guo-Qiang;Lu;Ying;Xia Li;Qin Kang;Wang Xin-Ran;Wang Xiao-Ling;Zhou Ai-Wu;Chen Guo-Qiang;Lu Y
5 Natural products against hematological malignancies and identification of their targets 期刊论文 Xu Ying;Liu JinBao;Wu YingLi;Guo QingLong;Sun HanDong;Chen GuoQiang
6 2-Bromopalmitate targets retinoic acid receptor alpha and overcomes all-trans retinoic acid resistance of acute promyelocytic leukemia 期刊论文 Lu Ying;Yan Jin Song;Xia Li;Qin Kang;Yin Qian Qian;Xu Hong Tao;Gao Meng Qing;Qu Xiao Ning;Sun Yu Ting;Chen Guo Qiang
7 ANP32B deficiency impairs proliferation and suppresses tumor progression by regulating AKT phosphorylation 期刊论文 Yang S;Zhou L;Reilly P T;Shen S-M;He P;Zhu X-N;Li C-X;Wang L-S;Mak T W;Chen G-Q;Yu Y
8 MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer 期刊论文 Wang Qiu Yu;Zhou Ci Xiang;Zhan Meng Na;Tang Jun;Wang Chen Long;Ma Cheng Ning;He Ming;Chen Guo Qiang;He Jian Rong;Zhao Qian
9 应激微环境调控肿瘤细胞命运的分子机制及其干预 奖励 陈国强;洪登礼;赵倩;赵克温;孙汉董
10 Autocrine epiregulin activates EGFR pathway for lung metastasis via EMT in salivary adenoid cystic carcinoma 期刊论文 Liu Shuli;Ye Dongxia;Xu Dongliang;Liao Yueling;Zhang Ling;Liu Liu;Yu Wenwen;Wang Yanan;He Yue;Hu Jingzhou;Guo Wenzheng;Wang Tong;Sun Beibei;Song Hongyong;Yin Huijing;Liu Jingyi;Wu Yadi;Zhu Hanguang;Zhou Binhua P;Deng Jiong;Zhang Zhiyuan
11 PTEN alpha and PTEN beta promote carcinogenesis through WDR5 and H3K4 trimethylation 期刊论文 Shen Shao Ming;Zhang Cheng;Ge Meng Kai;Dong Shuang Shu;Xia Li;He Ping;Zhang Na;Ji Yan;Yang Shuo;Yu Yun;Zheng Jun Ke;Yu Jian Xiu;Xia Qiang;Chen Guo Qiang
12 Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role 期刊论文 Shen;Shao-Ming;Ji;Yan;Zhang;Cheng;Dong;Shuang-Shu;Yang;Shuo;Xiong;Zhong;Ge;Meng-Kai;Shen Shao-Ming;Ji Yan;Zhang Cheng;Dong Shuang-Shu;Yang Shuo;Xiong Zhong;Ge Meng-Kai;Yu Yun;Xia Li;Guo Meng;Cheng Jin-Ke;Liu Jun-Ling;Yu Jian-Xiu;Chen Guo-Qiang
13 FAM122A, a new endogenous inhibitor of protein phosphatase 2A 期刊论文 Fan Li;Liu Man-Hua;Guo Meng;Hu Chuan-Xi;Yan Zhao-Wen;Chen Jing;Chen Guo-Qiang;Huang Ying
14 Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition 期刊论文 Tang;J.;Zhan;M-N;Yin;Q-Q;Zhou;C-X;Wang;C-L;Wo;L-L;He;M.;Chen;G-Q;Zhao;Q.;Tang J.;Chen G-Q;Zhan M-N;Yin Q-Q;Zhou C-X;Wang C-L;Wo L-L;He M.;Chen GQ;Zhao Q
15 Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis 期刊论文 Gu Hao;Chen Chiqi;Hao Xiaoxin;Wang Conghui;Zhang Xiaocui;Li Zhen;Shao Hongfang;Zeng Hongxiang;Yu Zhuo;Xie Li;Xia Fangzhen;Zhang Feifei;Liu Xiaoye;Zhang Yaping;Jiang Haishan;Zhu Jun;Wan Jiangbo;Wang Chun;Weng Wei;Xie Jingjing;Tao Minfang;Zhang Cheng Cheng;Liu Junling;Chen Guo-Qiang;Zheng Junke
16 Prognostic significance of Cbx4 expression and its beneficial effect for transarterial chemoembolization in hepatocellular carcinoma 期刊论文 Jiao H-K;Xu Y.;Li J.;Wang W.;Mei Z.;Long X-D;Chen G-Q
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