细胞对称与不对称分裂在Pten丢失引起的前列腺癌中的作用机制

81372189
2013
H1802.肿瘤发生
高维强
面上项目
教授
上海交通大学
75万元
Notch信号通路;肿瘤干细胞;C14_前列腺肿瘤;细胞对称分裂;Pten敲除
2014-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway 期刊论文 Zhou PJ;Xue W;Peng J;Wang Y;Wei L;Yang Z;Zhu HH;Fang YX;Gao WQ
2 WNT/beta-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT(high) Prostate Cancer Stem Cells 期刊论文 Zhang Kai;Guo Yanjing;Wang Xue;Zhao Huifang;Ji Zhongzhong;Cheng Chaping;Li Li;Fang Yuxiang;Xu Dawei;Zhu Helen He;Gao Wei-Qiang
3 MiR-302/367/LATS2/YAP Pathway is Essential for Prostate Tumor-Propagating Cells and Promotes the Development of Castration Resistance 期刊论文 Guo Y;Cui J;Ji Z;Cheng C;Zhang K;Chu M.;Zhao Q;Yu Z;Zhang Y;Fang Y.X;Gao W.Q.;Zhu H.H
4 Numb-/low enriches a castration resistant prostate cancer cell subpopulation associated with enhanced Notch and Hedgehog signaling 期刊论文 Guo Y;Zhang K;Cheng C;Ji Z;Wang X;Wang M;Chu M;Tang DG;Zhu HH;Gao WQ
5 Contributions of epithelial-mesenchymal transition and cancer stem cells to the development of castration resistance of prostate cancer 期刊论文 Li Ping;Yang Ru;Gao Wei-Qiang
6 Autocrine activation of CHRM3 promotes prostate cancer growth and castration resistance via CaM/CaMKK-mediated phosphorylation of Akt. 期刊论文 Naitao Wang;Ming Yao;Jin Xu;Yizhou Quan;Kaiqing Zhang;Ru Yang;Wei-Qiang Gao
7 Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status 期刊论文 Wang Naitao;Dong Bai-Jun;Quan Yizhou;Chen Qianqian;Chu Mingliang;Xu Jin;Xue Wei;Huang Yi-Ran;Yang Ru;Gao Wei-Qiang
8 Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition 期刊论文 K Zhang;H Zhao;Z Ji;C Zhang;P Zhou;L Wang;Q Chen;J Wang;P Zhang;Z Chen;H H Zhu;W-Q Gao
9 SKA1 over-expression promotes centriole over-duplication, centrosome amplification and prostate tumourigenesis 期刊论文 Li J;Xuan JW;Khatamianfar V;Valiyeva F;Moussa M;Sadek A;Yang BB;Dong BJ;Huang YR;Gao WQ
10 Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages 期刊论文 Jia Wang;Helen He Zhu;Mingliang Chu;Yunying Liu;Chenxi Zhang;Geng Liu;Xiaohang Yang;Ru Yang;Wei-Qiang Gao
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