SIRT1-HIF-1α信号通路对帕金森病多巴胺能神经元损伤的保护作用及其机制研究

81371410
2013
H0912.神经退行性变及相关疾病
吴云成
面上项目
主任医师
上海交通大学
70万元
缺氧诱导因子1alpha;脯氨酸羟化酶;沉默信息调节因子1;食欲素;帕金森病;A
2014-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Epigenetic mechanisms in Parkinson's disease 期刊论文 Feng Ya;Jankovic Joseph;Wu Yun-Cheng
2 Magnetofection based on superparamagnetic iron oxide nanoparticle-mediated low lncRNA HOTAIR expression decreases the proliferation and invasion of glioma stem cells 期刊论文 Fang Kan;Liu Peifeng;Dong Suyan;Guo Yanjie;Cui Xinxin;Zhu Xiaoying;Li Xuan;Jiang Lianghan;Liu Te;Wu Yuncheng
3 Neuroprotection by Orexin-A via HIF-1 alpha induction in a cellular model of Parkinson's disease 期刊论文 Feng Ya;Liu Te;Li Xin-Qun;Liu Ye;Zhu Xiao-Ying;Jankovic Joseph;Pan Tian-Hong;Wu Yun-Cheng
4 白藜芦醇通过SIRT1/AMPK信号通路减轻MPTP诱导的小鼠多巴胺能神经元丢失 期刊论文 郭彦杰;董素艳;赵文娟;吴云成
5 线粒体功能异常在帕金森病发病机制中的研究进展 期刊论文 冯娅;吴云成
6 MPTP小鼠脑沉默信息调节因子1和缺氧诱导因子-1α的表达及行为学检测 期刊论文 崔新新;董素艳;郭彦杰;赵文娟;吴云成
7 缺氧诱导因子-1在帕金森病发病机制中的研究进展 期刊论文 崔新新;吴云成
8 神经变性疾病的朊蛋白样作用机制研究进展 期刊论文 邱雨;吴云成
9 Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells 期刊论文 Feng Ya;Liu Te;Dong Su-Yan;Guo Yan-Jie;Jankovic Joseph;Xu Huaxi;Wu Yun-Cheng
10 Clinical features of Parkinson’s disease with and without rapid eye movement sleep behavior disorder 期刊论文 Ye Liu;Xiao-Ying Zhu;Xiao-Jin Zhang;Sheng-Han Kuo;William G. Ondo;Yun-Cheng Wu
11 microRNA-182 inhibits the proliferation and migration of glioma cells through the induction of neuritin expression 期刊论文 Feng Ya;Liu Te;Wu Yuncheng
12 Effects of deep brain stimulation in relatively young-onset multiple system atrophy Parkinsonism 期刊论文 Zhu Xiao-Ying;Pan Tian-Hong;Ondo William G.;Jimenez-Shahed Joohi;Wu Yun-Cheng
13 Clinical characteristics of leg restlessness in Parkinson's disease compared with idiopathic Restless Legs Syndrome 期刊论文 Zhu Xiao-Ying;Liu Ye;Zhang Xiao-Jin;Yang Wen-Hao;Feng Ya;Undo William G.;Tan Eng-King;Wu Yun-Cheng
14 The epigenetic regulation of HIF-1 alpha by SIRT1 in MPP+ treated SH-SY5Y cells 期刊论文 Dong Su-Yan;Guo Yan-Jie;Feng Ya;Cui Xin-Xin;Kuo Sheng-Han;Liu Te;Wu Yun-Cheng
15 SIRT3 deacetylated and increased citrate synthase activity in PD model 期刊论文 Cui Xin-Xin;Li Xuan;Dong Su-Yan;Guo Yan-Jie;Liu Te;Wu Yun-Cheng
16 HIF-1α 小分子激活剂 FG-4592 在帕金森病中的应用 专利 吴云成;尹慧勇;李璇
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