阿尔茨海默氏症天然药物的设计、筛选以及相关的理论研究

30870476
2008
C0504.物理生物学
魏冬青
面上项目
教授
上海交通大学
30万元
阿尔茨海默氏症;老年痴呆;计算机辅助药物设计;α7烟碱样乙酰胆碱受体
2009-01-01到2011-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Novel Positive Allosteric Modulators of the Human alpha 7 Nicotinic Acetylcholine Receptor 期刊论文
2 Free Energy Calculations on the Two Drug Binding Sites in the M2 Proton Channel 期刊论文
3 Long-Range Effects of a Surface Mutation on the Enzymatic Activity of Cytochrome P450 1A2 期刊论文
4 Insights from investigating the interactions of adamantane-based drugs with the M2 proton channel from the H1N1 swine virus 期刊论文
5 Different Interaction between the Agonist JN403 and the Competitive Antagonist Methyllycaconitine with the Human alpha 7 Nicotinic Acetylcholine Receptor 期刊论文
6 Structural Basis of Agonist Selectivity for Different nAChR Subtypes: Insights from Crystal Structures, Mutation Experiments and Molecular Simulations 期刊论文
7 Predicting Protein-Ligand Binding Sites Based on an Improved Geometric Algorithm 期刊论文
8 An Allosteric Mechanism Inferred from Molecular Dynamics Simulations on Phospholamban Pentamer in Lipid Membranes 期刊论文
9 Molecular Dynamics Studies on T1 Lipase: Insight into a Double-Flap Mechanism 期刊论文
10 Free Energy Calculations and Binding Analysis of two Potential Anti-Influenza Drugs with Polymerase Basic Protein-2 (PB2) 期刊论文
11 Tethered-Hopping Model for Protein-DNA Binding and Unbinding Based on Sox2-Oct1-Hoxb1 Ternary Complex Simulations 期刊论文
12 Molecular dynamics studies on the interactions of PTP1B with inhibitors: from the first phosphate-binding site to the second one 期刊论文
13 Possible Drug Candidates for Alzheimer';s Disease Deduced from Studying their Binding Interactions with alpha 7 Nicotinic Acetylcholine Receptor 期刊论文
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