帕金森病早期诊断生物学标记及基因靶向治疗研究

30730096
2007
H0912.神经退行性变及相关疾病
乐卫东
重点项目
教授
上海交通大学
150万元
生物标记;Nurr1基因;突变;帕金森病;激活剂
2008-01-01到2011-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Nurr1 expression and its modulation in microglia. 期刊论文
2 Thapsigargin- induced Ca(2+) increase inhibits TGFbeta1-mediated Smad2 transcriptional responses via Ca(2+)/calmodulin-dependent protein kinase II. 期刊论文
3 Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson’s disease. 期刊论文
4 Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons. 期刊论文
5 Nr4a2 is essential for the differentiation of dopaminergic neurons during zebrafish embryogenesis. 期刊论文
6 Critical role of lysosome and its associated protein cathepsin D in manganese-induced toxicity in cultured midbrain astrocyte. 期刊论文
7 Prevention of Motor Neuron Degeneration by Novel Iron Chelators in SOD1G93A Transgenic Mice of Amyotrophic Lateral Sclerosis. 期刊论文
8 Autophagy dysfunction in Alzheimer's disease. 期刊论文
9 Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures. 期刊论文
10 Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons. 期刊论文
11 Rapamycin treatment augments motor neuron degeneration in SOD1 (G93A) mouse model of amyotrophic lateral sclerosis. 期刊论文
12 Long-Term Treatment with Lithium Alleviates Memory Deficits and Reduces Amyloid-β Production in an Aged Alzheimer's Disease Transgenic Mouse Model. 期刊论文
13 Folic acid protects motor neurons against the increased homocysteine, inflammation and apoptosis in SOD1G93A transgenic mice 期刊论文
14 Sall3 Correlates with the Expression of TH in Mouse Olfactory Bulb. 期刊论文
15 An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity 期刊论文
16 中脑多巴胺系统发育及神经元变性在帕金森病中的基因调控和分子机制 奖励
17 Dopamine neuron degeneration induced by MPP+ is independent of CED-4 pathway in Caenorhabditis elegans. 期刊论文
18 Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo. 期刊论文
19 Collective roles of molecular chaperones in protein degradation pathways associated with neurodegenerative diseases. 期刊论文
20 Mifepristone inducible caspase-1 expression in mouse embryonic stem cells eliminates tumor formation but spares differentiated cells in vitro and in vivo. 期刊论文
21 Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease. 期刊论文
22 Gender segregation in gene expression and vulnerability to oxidative stress induced injury in ventral mesencephalic cultures of dopamine neurons. 期刊论文
23 Decreased level of 5-methyltetrahydrofolate: a potential biomarker for pre-symptomatic amyotrophic lateral sclerosis. 期刊论文
24 自噬-生物学与疾病 专著
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