【30700335】PRDM1基因beta异构型在弥漫大B细胞性淋巴瘤中的表达及其生物学作用国家自然基金项目

PRDM1基因beta异构型在弥漫大B细胞性淋巴瘤中的表达及其生物学作用

项目批准号： 30700335

批准年份： 2007

学科分类： H0810.淋巴瘤与淋巴细胞疾病

项目负责人：赵维莅

资助类别：青年科学基金项目

负责人职称：主任医师

依托单位：上海交通大学

资助金额： 17万元

关键词： B细胞分化;弥漫性大B细胞淋巴瘤;PRDM1

起止时间： 2008-01-01到2010-12-31

中英文摘要
结题摘要
结题报告
项目成果
项目参与人

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序号	标题	类型	作者
1	AML1-ETO 9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2	期刊论文	Wang YY\|Wang JH\|Chen Z\| Li JM\|Wu CF\|Chen Y\|Jiao B\|Liang Y\|Xiong SM\|Gu LJ\|Shen ZX\| Chen HM\|Tang JY\|Zhao WL\|Gu BW\|Chen SJ\| Chen B\|Shi JY\|
2	Bevacizumab potentiates chemotherapeutic effect on T-leukemia/lymphoma cells by direct action on tumor endothelial cells	期刊论文	Zhao WL\|Janin A\|Varna M\|Wang L \|Leboeuf C\|Shi WY\|Chen SJ\|Tang W\|Shen ZX\|Gapihan G\|Yang F\|
3	NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis	期刊论文	Gao XD\|Jiang H\|Chen B\| Liang H\|Tang JY\|Hu J\|Shen ZX\|Zhao WL\|Li JM\|Chen SJ\|Chen Z\|Pan Q\|Xue YQ\|Shi JY\|Fu JF\|Zhu YM\|Gu LJ\|Xiong SM\|
4	Cytostatic and anti-angiogenic effects of temsirolimus in refractory mantle cell lymphoma	期刊论文	Zhao WL\|Wu ZY\|Lu H\|Varna M\|Wang L\|Janin A\| Shen ZX\| Wang AH\| Zhou L\|Shi WY\|Chen L\|
5	The myelodysplastic syndromes: analysis of prognostic factors and comparison of prognostic systems in 128 Chinese patients from a single institution	期刊论文	Chen Z\|Wu W\|Zeng XY\|Yan H\|Hu J\|Xiong SM\|Chen SJ\|Shen ZX\|Xu L\|Li JM\|Tang W\|Chen Y\|Wang ZY\|Zhao WL\|
6	Retinoic acid and arsenic for treating acute promyelocytic leukemia	期刊论文	Zhou GB\|Wang ZY\|Chen Z\|Zhao WL\|Chen SJ\|
7	Molecular cytogenetic characterization and clinical relevance of additional, complex and/or variant chromosome abnormalities in acute promyelocytic leukemia	期刊论文	Xu L\|Shen ZX\|Wang C\|Cao Q\|Chen Z\|Su XY\|Chen SJ\|Zhao M\|Xiong SM\|Zhao WL\|Gao YR\| Gu J\|Hu J\|Zhu YM\|Niu C\|Yan H\|Gu BW\|
8	Rituximab plus CHOP (R-CHOP) overcomes PRDM1-associated resistance to chemotherapy in patients with diffuse large B-cell lymphoma	期刊论文	Shen Y\|Wang L\|Janin A\| Li JM\|Shen ZX\|Chen Z\|Shi JY\|Liu YY\|Garcia JF\|Chen SJ\|Zhao WL\|Leboeuf C\|
9	MassARRAY assay: a more accurate method for JAK2V 617F mutation detection in Chinese patients with myeloproliferative disorders	期刊论文	Li JM\|Shen ZX\|Jin J\|Hu J\|Pan Q\|Chen FY\|Shi JY\|Li G\|Zhao WL\|Fu JF\|Chen SJ\|
10	Treatment of acute promyelocytic leukemia with arsenic trioxide: clinical and basic studies	期刊论文	Chen GQ\|Xu L\|Zhao WL\|Chen SJ\|Cai X\|Shen ZX\|Chen Z\|Shen Y\|Wang ZY.\|
11	Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia.	期刊论文	Li JM\|Chen SJ\|Xu F\|Waxman S\|Hu J\|Sun HP\|Zhao WL\|Chen Z\| Liu YF\|Wu W\|Chen QS\|Zhou GB\|Zhu YM\|Wang ZY\| Zelent A\| Wu CF\| Chen B\|Shen ZX\|
12	淋巴系肿瘤疾病进展分子标志物和靶向治疗	奖励	赵维莅\|
13	Proteasome inhibitor bortezomib targeted tumor-endothelial cell interaction in T-cell leukemia/lymphoma	期刊论文	Xiao D\|Zhao WL\|Wang L\|Jiang XX\|Shi WY\|Janin A\|Yao Y\|Leboeuf C\|Chen SJ\|Yang F\|
14	Prognostic significance of bcl-xL gene expression and apoptotic cell counts in follicular lymphoma	期刊论文	Brière J\|Turpin E\|Leboeuf C\|Mounier N\|Cayuela JM\|Janin A\|Plassa LF\|Gisselbrecht C\|Daneshpouy ME\|Ameisen JC\|Zhao WL\|
15	Arsenic trioxide and acute promyelocytic leukemia: clinical and biological	期刊论文	Guillemin MC\|Vitoux D\|Zhao WL\|Zhu J\|Li JM\|Chen SJ\|Shen ZX\|Chen Z\|Lallemand-Breittenbach V\|Zhou J\|de Thé H.\|
16	The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis	期刊论文	Zhang YW\|Zhao WL\|Zhang QL\|Yang F\|Wu WL\|Janin A\|Wang L\|Jiang XX\|Shen ZX\|Chen SJ\|Chen Z\|
17	Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents.	期刊论文	Pan L\|Wang HL\|Zhu J\|Sun GL\|Chen SJ\|Zhao WL\|Yao YY\|Wang ZY\|Chen GQ\|Caen J\|Ju B\|Chen Z\|Cai X\|Guo WM\|
18	Studies on the clinical efficacy and pharmacokinetics of low-dose arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia: a comparison with conventional dosage.	期刊论文	Shen ZX\|Xiong SM\|Shen Y\|Wu F\|Chen J\|Chen Z\|Tang W\|Zhao WL \|Niu C\|Li XS\|Wu W\|Chen SJ\|Zeng XY\|Liu YF\|Yan H\|Li JM\|Wang ZY\|
19	Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries	期刊论文	Cao Q\|Li JM\|Chen B\|Yao Y\|Xiong SM\|Chen ZM\|Xia HL\|Chen J\|Zhao WL\|Jin J\|Cheng X\| Tong JH\|Waxman S\|Chen SJ\|Xue YQ\|Shen ZX\|Cui J\|Chen Z\|Chen XT\|Yang G\|
20	Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways	期刊论文	赵维莅\|
21	Vascular endothelial growth factor-A is expressed both on lymphoma cells and endothelial cells in angioimmunoblastic T-cell lymphoma and related to lymphoma progression	期刊论文	Calvo F\| Gisselbrecht C\|Mounier N\|Meignin V\|Leboeuf C\|Janin A\|Legrès L\| Brière J\|Mourah S\|Zhao WL\|Oksenhendler E\| Maignin CL\| Daneshpouy ME\|
22	FIP 1L 1-PDGFRalpha alone or with other genetic abnormalities reveals disease progression in chronic eosinophilic leukemia but good response to imatinib	期刊论文	Shi JY\| Zhao WL\| Fu JF\|Jin J\|Hu J\| Chen SJ\|Chen Z\|Wang LN\|Li JM\|Pan Q\|
23	The prognostic value of immunohistochemical subtyping in Chinese patients with de novo diffuse large B-cell lymphoma undergoing CHOP or R-CHOP treatment	期刊论文	Chen QS\|Zhu Q\|Zhao SQ\|Xu ZZ\|Zheng Y\|Li JM\|Zhao WL\|Hu JP\|Chen Y\|Shen ZX\|Xia ZG\|Ding F\|
24	Loss of promoter methylation contributes to the expression of functionally impaired PRDM1β isoform in diffuse large B-cell lymphoma	期刊论文	Zhao WL\|Jiao B\|Chen SJ\|Chen Y\|Shen ZX\|Zhang YW\| Xie HQ\|
25	Feasibility and clinical significance of real-time quantitative RT-PCR assay of PML-RARalpha fusion transcript in patients with acute promyelocytic leukemia	期刊论文	Ying HY\| Gu J\|Chen SJ\|Chen Z\|Niu C\|Shen ZX\|Yan H\|Hu J\|Gu BW\|Cao Q\|Chen Y\|Zhao WL\|Zhu YM\|Jin WR\|Xu L\|Su XY\|Xiong SM\|
26	Bcl-xL gene expression correlated with lower apoptotic cell numbers and shorter progression-free survival in PCFCL	期刊论文	Bachelez H\|Soltani-Arabshahi R\|Leboeuf C\| Zhao WL\|Rivet J, Pisonero H\|Janin A\|Ameisen JC\|
27	Combined effects of histone deacetylase inhibitor and rituximab on non-Hodgkin's B-lymphoma cells apoptosis.	期刊论文	Chen Z\|Wang L\|Liu YY\|Janin A\|Liu YH\|Wu WL\|Chen SJ\|Leboeuf C\|Zhao WL\| Yan JS\|
28	Eriocalyxin B induces apoptosis in lymphoma cells through multiple cellular signaling pathways	期刊论文	Sun HD\|Wang L\|Shi WY\|Zhao WL\|Chen Z\| Jiang XX\|Chen QS\|Chen SJ\|Zhang YW\|Shen ZX\|
29	Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner	期刊论文	Yan JS\|Weng XQ\|Sun HP\|Wang L\|Zhao WL\|Chen Z\|Wu WL\|Liu P\| Sun XJ\|Zhou GB\| Weng ZY\|Sun HD\|
30	Effects of all-trans-retinoic acid and arsenic trioxide on the hemostatic disturbance associated with acute promyelocytic leukemia	期刊论文	Zhao WL\|Wang XF\| Wu F\|Qu B\|Wang Z\|Wang HL\|Guo W\|Shen Z\|
31	Clinical significance of plasma tissue factor pathway and urokinase-type plasminogen activator system in cancer patients	期刊论文	Qu B\|Wang H\|Wang XF\|Zhao WL\|Huang X\|
32	Hemostatic abnormalities associated with acute promyelocytic leukemia and corrective effects of all-trans-retinoic acid or arsenic trioxide treatment.	期刊论文	Zhao WL\|Qu B\|Wang Z.\|Shen Z\|Wang X\|Wang H\|Chen Z\|Guo W\|
33	Proteasome inhibitor bortezomib targeted tumor-endothelial cell interaction in T-cell leukemia/lymphoma	期刊论文	Xiao D\|Zhao WL\|Wang L\|Jiang XX\|Shi WY\|Janin A\|Yao Y\|Leboeuf C\|Chen SJ\|Yang F\|
34	PRDM1 is involved in chemoresistance of T-cell lymphoma and down-regulated by the proteasome inhibitor	期刊论文	Zhao WL\|Song YP\|Chen SJ\|Chen Z\|Shen ZX\|Garcia JF\|Zhang QL\|Ma J\|Wang L\|Leboeuf C\|Zhang YW\| Li JM\|Liu YY\|Janin A\|

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