分子伴侣AChE诱导Aβ寡聚体形成的动力学和膜离子通道改变的研究

30973509
2009
H3501.神经精神药物药理
陈红专
面上项目
教授
上海交通大学
32万元
乙酰胆碱酯酶;阿尔茨海默病;寡聚化;淀粉样多肽;离子通道
2010-01-01到2012-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 阿尔茨海默病及相关认知障碍的发病机制和诊治的基础与临床 奖励 陈红专|
2 Novel bis-(-)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property 期刊论文 Zheng W.|Hu Z.|Zhou W.|Shao B.|Cui Y.|Xie Q.|Chen H.|Li J.|Qiu Z.|Xia Z.|Li W.|Yu L.|Chen H.|Chen J.|Chen Y.|
3 The newly identified K+ channel blocker talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons 期刊论文 Wang, Yanxia|Song, Mingke|Hou, Lina|Yu, Zhihua|Chen, Hongzhuan|
4 α-Mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation 期刊论文 Wang Y.|Xia Z.|Xu J.-R.|Wang Y.-X.|Hou L.-N.|Qiu Y.|Chen H.-Z.|
5 Determination of Bis(9)-(-)-Meptazinol, a bis-ligand for Alzheimer';s disease, in rat plasma by liquid chromatography-tandem mass spectrometry: Application to pharmacokinetics study 期刊论文 Ge, Xin-xing|Wang, Hao|Chen, Hong-zhuan|Wang, Xiao-lin|Jiang, Pan|Xie, Ying|Jiang, Tao|Rong, Zheng-xing|Zhang, Qi-zhi|Xie, Qiong|Qiu, Zhui-bai|
6 Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice 期刊论文 Liu T|Xie Q|Wang H|Chen HZ|Xia Z|Zhang WW|Xu JR|Ge XX|Li J|Cui Y|Qiu ZB|Xu J|
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