中药体内过程与机理

81325025
2013
H3216.中药代谢与药物动力学
郝海平
国家杰出青年科学基金
教授
中国药科大学
200万元
中药药代动力学;复杂成分分析;代谢机理;体内过程;
2014-01至2017-12
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor a–Mediated Apoptosis 期刊论文 Tingting Yan;Hong Wang;Min Zhao;Tomoki Yagai;Yingying Chai;Kristopher W.Krausz;Cen Xie;Xuefang Cheng;Jun Zhang;Yuan Che;Feiyan Li;Yuzheng Wu;Chad N. Brocker;Frank J. Gonzalez;Guangji Wang;Haiping Hao
2 Insights into drug discovery from natural medicines using reverse pharmacokinetics 期刊论文 Haiping Hao;Xiao Zheng;Guangji Wang
3 大挑战2015·青年科学家 奖励 彭宗根
4 Characterization of isochlorogenic acid A metabolites in rats using high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry 期刊论文 Wang Jing;Cao Guoxiu;Wang Hong;Ye Hui;Zhong Yunxi;Wang Guangji;Hao Haiping
5 Stepped MSAll Relied Transition (SMART): An approach to rapidly determine optimal multiple reaction monitoring mass spectrometry parameters for small molecules 期刊论文 Hui Ye();Lin Zhu();Lin Wang;Huiying Liu;Jun Zhang;Mengqiu Wu;Guangji Wang();Haiping Hao()
6 Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis 期刊论文 Hao;Haiping;Cao;Lijuan;Jiang;Changtao;Che;Yuan;Zhang;Songyang;Takahashi;Shogo;Wang;Guangji;Gonzalez;Frank J.;Hao Haiping;Cao Lijuan;Jiang Changtao;Che Yuan;Zhang Songyang;Takahashi Shogo;Wang Guangji;Gonzalez Frank J.
7 Stepped collisional energy MSAll: an analytical approach for optimal MS/MS acquisition of complex mixture with diverse physicochemical properties 期刊论文 Ye Hui();Wang Lin;Zhu Lin;Sun Di;Luo Xiaozhuo;Wang Hong;Wang Guangji();Hao Haiping()
8 Metabolic Pathway Extension Approach for Metabolomic Biomarker Identification 期刊论文 Wang Lin;Ye Hui;Sun Di;Meng Tuo;Cao Lijuan;Wu Mengqiu;Zhao Min;Wang Yun;Chen Baoqiang;Xu Xiaowei;Wang Guangji;Hao Haiping
9 Nontargeted diagnostic ion network analysis (NINA): A software to streamline the analytical workflow for untargeted characterization of natural medicines 期刊论文 Hui Ye();Lin Zhu();Di Sun;Xiaozhuo Luo;Gaoyuan Lu;Hong Wang;Jing Wang;Guoxiu Cao;Wei Xiao;Zhenzhong Wang;Guangji Wang();Haiping Hao()
10 De-novo NAD(+) synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells 期刊论文 Liu Huiying;Xing Rong;Cheng Xuefang;Li Qingran;Liu Fang;Ye Hui;Zhao Min;Wang Hong;Wang Guangji;Hao Haiping
11 Conjugation site analysis of antibody-drug-conjugates (ADCs) by signature ion fingerprinting and normalized area quantitation approach using nano-liquid chromatography coupled to high resolution mass spectrometry 期刊论文 Hua Sang();Gaoyuan Lu;Yazhong Liu;Qiyue Hu;Weifeng Xing;Dongbing Cui;Fang Zhou;Jingwei Zhang;Haiping Hao;Guangji Wang();Hui Ye()
12 UDP-Glucuronosyltransferase 1A Determinates Intracellular Accumulation and Anti-Cancer Effect of beta-Lapachone in Human Colon Cancer Cells 期刊论文 Liu Huiying;Li Qingran;Cheng Xuefang;Wang Hong;Wang Guangji;Hao Haiping
13 Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way? 期刊论文 Zheng, Xiao,Zhang, Xueli,Kang, An,Ran, Chongzhao,Wang, Guangji,Hao, Haiping
14 Isochlorogenic acid A affects P450 and UGT enzymes in vitro and in vivo 期刊论文 Wang Jing;Wang Hong;Peng Ying;Wang Guang Ji;Hao Hai Ping
15 Chemical dampening of Ly6Chi monocytes in the periphery produces anti-depressant effects in mice 期刊论文 Wang lin|Wang qiong|Wang guangji|Hao Haiping|
16 Farnesoid X receptor activation promotes cell proliferation via PDK4-controlled metabolic reprogramming 期刊论文 Xie Yang;Wang Hong;Cheng Xuefang;Wu Yuzheng;Cao Lijuan;Wu Mengqiu;Xie Wen;Wang Guangji;Hao Haiping
17 Ginsenosides Regulate PXR/NF-kappa B Signaling and Attenuate Dextran Sulfate Sodium-Induced Colitis 期刊论文 Zhang Jun;Cao Lijuan;Wang Hong;Cheng Xuefang;Wang Lin;Zhu Lin;Yan Tingting;Xie Yang;Wu Yuzheng;Zhao Min;Ma Sijing;Wu Mengqiu;Wang Guangji;Hao Haiping
18 Comparison of bioactive components and pharmacological activities of ophiopogon japonicas extracts from different geographical origins 期刊论文 Zhao Min();Xu Wan-feng;Shen Han-yuan;Shen Pei-qiang;Zhang Jun;Wang Dan-dan;Xu Han;Wang Hong;Yan Ting-ting;Wang Lin;Hao Hai-ping;Wang Guang-ji();Cao Li-juan()
19 Mechanism-Based Inhibitory and Peroxisome Proliferator-Activated Receptor alpha-Dependent Modulating Effects of Silybin on Principal Hepatic Drug-Metabolizing Enzymes 期刊论文 Wang Hong;Yan Tingting;Xie Yuan;Zhao Min;Che Yuan;Zhang Jun;Liu Huiying;Cao Lijuan;Cheng Xuefang;Xie Yang;Li Feiyan;Qi Qu;Wang Guangji;Hao Haiping
20 Metabolomics-Proteomics Combined Approach Identifies Differential Metabolism-Associated Molecular Events between Senescence and Apoptosis 期刊论文 Wu Mengqiu;Ye Hui;Shao Chang;Zheng Xiao;Li Qingran;Wang Lin;Zhao Min;Lu Gaoyuan;Chen Baoqiang;Zhang Jun;Wang Yun;Wang Guangji;Hao Haiping
21 NAMPT inhibition synergizes with NQO1-targeting agents in inducing apoptotic cell death in non-small cell lung cancer cells 期刊论文 Liu Hui-Ying();Li Qing-Ran;Cheng Xue-Fang;Wang Guang-Ji();Hao Hai-Ping()
22 PPAR alpha-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis 期刊论文 Zhou Xueyan;Cao Lijuan;Jiang Changtao;Xie Yang;Cheng Xuefang;Krausz Kristopher W.;Qi Yunpeng;Sun Lu;Shah Yatrik M.;Gonzalez Frank J.;Wang Guangji;Hao Haiping
23 新型FXR激动剂的合成和应用 专利 郝海平;徐小为;赵洲;王洪
24 Ginsenosides synergize with mitomycin C in combating human non-small cell lung cancer by repressing Rad51-mediated DNA repair 期刊论文 Zhao Min();Wang Dan dan;Che Yuan;Wu Meng qiu;Li Qing ran;Shao Chang;Wang Yun;Cao Li juan;Wang Guang ji();Hao Hai ping()
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