蛋白质翻译后修饰与肿瘤发生发展及转移的分子机制研究
81321003
2013
H1802.肿瘤发生
朱卫国
创新研究群体项目
教授
北京大学
600万元
蛋白质翻译后修饰;肿瘤发生;肿瘤转移;组蛋白修饰;
2014-01至2016-12
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Targeting Histone Deacetylases for Cancer Therapy: From Molecular Mechanisms to Clinical Implications | 期刊论文 | Li Zhiming;Zhu Wei-Guo |
| 2 | Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62 | 期刊论文 | Wang Yanan();Zhang Nan;Zhang Luyao;Li Ran;Fu Wan;Ma Ke;Li Xue;Wang Lina;Wang Jiadong;Zhang Hongquan;Gu Wei;Zhu Wei-Guo;Zhao Ying() |
| 3 | 含有多种酶活性的SIRT5蛋白在细胞代谢中的功能 | 期刊论文 | 杨鑫();刘博雅;朱卫国;罗建沅() |
| 4 | The Batten disease gene CLN3 confers resistance to endoplasmic reticulum stress induced by tunicamycin | 期刊论文 | Wu Dan;Liu Jing;Wu Baiyan;Tu Bo;Zhu Weiguo;Luo Jianyuan |
| 5 | Biochemical and structural characterization of a DNA N6-adenine methyltransferase from Helicobacter pylori. | 期刊论文 | Chen, Huiling|Ding, Jingjin|Liu, Wei|Zhang, Hongquan| |
| 6 | PTEN stabilizes TOP2A and regulates the DNA decatenation | 期刊论文 | Xi Kang;Chang Song;Xiao Du;Cong Zhang;Yu Liu;Ling Liang;Jinxue He;Kristy Lamb;Wen H.Shen;Yuxin Yin |
| 7 | EZH2 is required for mouse oocyte meiotic maturation by interacting with and stabilizing spindle assembly checkpoint protein BubRI | 期刊论文 | Qu Yi();Lu Danyu;Jiang Hao;Chi Xiaochun;Zhang Hongquan() |
| 8 | FERM domain-containing unconventional myosin VIIA interacts with integrin beta 5 subunit and regulates alpha v beta 5-mediated cell adhesion and migration | 期刊论文 | Liu Yuqing();Guan Lizhao;Zhan Jun;Lu Danyu;Wan Junhu;Zhang Hongquan() |
| 9 | 组蛋白修饰酶类参与肿瘤细胞氧化应激的机制研究 | 奖励 | 朱卫国;赵颖;王丽娜;刘向宇;王冬来;张萍;周静怡;王海英;杨洋;杨静;曹林林 |
| 10 | Histone modifications in DNA damage response | 期刊论文 | Cao Lin-Lin;Shen Changchun;Zhu Wei-Guo |
| 11 | Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway | 期刊论文 | Fu-Zheng Wei();Ziyang Cao();Xi Wang;Hui Wang;Mu-Yan Cai;Tingting Li;Naoko Hattori;Donglai Wang;Yipeng Du;Boyan Song;Lin-Lin Cao;Changchun Shen;Lina Wang;Haiying Wang;Yang Yang;Dan Xie;Fan Wang;Toshikazu Ushijima;Ying Zhao();Wei-Guo Zhu() |
| 12 | PTEN Controls the DNA Replication Process through MCM2 in Response to Replicative Stress | 期刊论文 | Feng Jiawen();Liang Jing();Li Jiaju;Li Yunqiao;Liang Hui;Zhao Xuyang;McNutt Michael A.;Yin Yuxin() |
| 13 | Molecular Imaging of Tumor-Infiltrating Macrophages in a Preclinical Mouse Model of Breast Cancer | 期刊论文 | Sun Xianlei();Gao Duo;Gao Liquan;Zhang Chenran;Yu Xinhe;Jia Bing;Wang Fan;Liu Zhaofei() |
| 14 | Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology | 期刊论文 | Liu Ying;Lu Zheming;Xu Ruiping;Ke Yang |
| 15 | P2Y2 Receptor and EGFR Cooperate to Promote Prostate Cancer Cell Invasion via ERK1/2 Pathway | 期刊论文 | Li WH;Qiu Y;Zhang HQ;Tian XX;Fang WG |
| 16 | Kindlin-2 interacts with alpha-actinin-2 and beta 1 integrin to maintain the integrity of the Z-disc in cardiac muscles | 期刊论文 | Lu, Danyu|Song, Yao|Zhang, Youyi|Zhang, Hongquan| |
| 17 | Depletion of Kindlin-2 induces cardiac dysfunction in mice | 期刊论文 | Qi Lihua();Yu Yu;Chi Xiaochun;Lu Danyu;Zhang Hongquan;Qi Lihua;Yu Yu;Chi Xiaochun;Lu Danyu;Zhang Hongquan;Qi Lihua;Yu Yu;Chi Xiaochun;Lu Danyu;Zhang Hongquan;Song Yao;Zhang Youyi;Song Yao;Zhang Youyi;Zhang HQ();Zhang HQ() |
| 18 | Lu-177-Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics | 期刊论文 | Jing Lijia;Shi Jiyun;Fan Di;Li Yaqian;Liu Renfa;Dai Zhifei;Wang Fan;Tian Jie |
| 19 | Kindlin-2 expression in adult tissues correlates with their embryonic origins | 期刊论文 | Zhan Jun();Yang Mei;Chi XiaoChun;Zhang Jing;Pei XueLian;Ren CaiXia;Guo YongQing;Liu Wei;Zhang HongQuan() |
| 20 | Genetic Polymorphisms of TGFB1, TGFBR1, SNAI1 and TWIST1 Are Associated with Endometrial Cancer Susceptibility in Chinese Han Women | 期刊论文 | Yang L|Wang YJ|Zheng LY|Fang WG| |
| 21 | PRC2 regulates RNA polymerase III transcribed non-translated RNA gene transcription through EZH2 and SUZ12 interaction with TFIIIC complex | 期刊论文 | Liu Chang();Li Shuai();Dai Xiaoyan;Ma Ji;Wan Junhu;Jiang Hao;Wang Peng;Liu Zhaoli;Zhang Hongquan() |
| 22 | Kindlin-2 induced by TGF-beta signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9 | 期刊论文 | Zhan Jun();Song Jiagui;Wang Peng;Chi Xiaochun;Wang Yunling;Fang Weigang;Zhang Hongquan();Song Jiagui;Wang Peng;Chi Xiaochun;Wang Yunling;Fang Weigang;Zhang Hongquan;Zhan Jun;Song Jiagui;Wang Peng;Chi Xiaochun;Wang Yunling;Zhang Hongquan;Guo Yongqing;Fang Weigang;Fang WG() |
| 23 | Kindlin-2 interacts with and stabilizes EGFR and is required for EGF-induced breast cancer cell migration | 期刊论文 | Liu Yuqing;Guan Lizhao;Zhan Jun;Lu Danyu;Wan Junhu;Zhang Hongquan |
| 24 | USP9X destabilizes pVHL and promotes cell proliferation | 期刊论文 | Liu, Yu|Jin, Yan|McNutt, Michael A.|Yin, Yuxin| |
| 25 | Enhanced IMP3 Expression Activates NF-kappa B Pathway and Promotes Renal Cell Carcinoma Progression | 期刊论文 | Pei Xuelian;Li Muhan;Zhan Jun;Yu Yu;Wei Xiaofan;Guan Lizhao;Aydin Hakan;Elson Paul;Zhou Ming;He Huiying;Zhang Hongquan() |
| 26 | SET7/9 regulates cancer cell proliferation by influencing beta-catenin stability | 期刊论文 | Shen Changchun;Wang Donglai;Liu Xiangyu;Gu Bo;Du Yipeng;Wei Fu-Zheng;Cao Lin-Lin;Song Boyan;Lu Xiaopeng;Yang Qiaoyan;Zhu Qian;Hou Tianyun;Li Meiting;Wang Lina;Wang Haiying;Zhao Ying;Yang Yang;Zhu Wei-Guo |
| 27 | Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion | 期刊论文 | Zhang Ping;Tu Bo;Wang Hua;Cao Ziyang;Tang Ming;Zhang Chaohua;Gu Bo;Li Zhiming;Wang Lina;Yang Yang;Zhao Ying;Wang Haiying;Luo Jianyuan;Deng Chu-Xia;Gao Bin;Roeder Robert G.;Zhu Wei-Guo |
| 28 | Integrin alpha(v)beta(6)-Targeted SPECT Imaging for Pancreatic Cancer Detection | 期刊论文 | Liu Zhaofei;Liu Hao;Ma Teng;Sun Xianlei;Shi Jiyun;Jia Bing;Sun Yi;Zhan Jun;Zhang Hongquan;Zhu Zhaohui;Wang Fan |
| 29 | Kindlin-2 phosphorylation by Src at Y193 enhances Src activity and is involved in Migfilin recruitment to the focal adhesions | 期刊论文 | Liu Zhaoli();Lu Danyu;Wang Xiang;Wan Junhu;Liu Chang;Zhang Hongquan() |
| 30 | SPECT/NIRF Dual Modality Imaging for Detection of Intraperitoneal Colon Tumor with an Avidin/Biotin Pretargeting System | 期刊论文 | Chengyan Dong;Sujuan Yang;Jiyun Shi;Huiyun Zhao;Lijun Zhong;Zhaofei Liu;Bing Jia;Fan Wang |
| 31 | PTEN regulates RPA1 and protects DNA replication forks | 期刊论文 | Wang Guangxi();Li Yang();Wang Pan;Liang Hui;Cui Ming;Zhu Minglu;Guo Limei;Su Qian;Sun Yujie;McNutt Michael A.;Yin Yuxin() |
| 32 | Ga-68-Labeled 3PRGD(2) for Dual PET and Cerenkov Luminescence Imaging of Orthotopic Human Glioblastoma | 期刊论文 | Fan Di;Zhang Xin;Zhong Lijun;Liu Xujie;Sun Yi;Zhao Huiyun;Jia Bing;Liu Zhaofei;Zhu Zhaohui;Shi Jiyun;Wang Fan |
| 33 | PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression | 期刊论文 | Wan;J.;Zhan;J.;Li;S.;Ma;J.;Xu;W.;Liu;C.;Xue;X.;Xie;Y.;Fang;W.;Chin;Y. E.;Zhang;H. |
| 34 | New pyridin-3-ylmethyl carbamodithioic esters activate pyruvate kinase M2 and potential anticancer lead compounds | 期刊论文 | Yu Zhang;Bin Liu;Xingyu Wu;Ridong Li;Xianling Ning;Yu Liu;Zhenming Liu;Zemei Ge;Runtao Li;Yuxin Yin |
| 35 | Identification of a FOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma | 期刊论文 | Li Xiaofeng;Peng Jirun;Pang Yanli;Yu Sen;Yu Xin;Chen Pengcheng;Wang Wenzhen;Han Wenling;Zhang Jun;Yin Yanhui;Zhang Yu |
| 36 | Biological function and regulation of histone and non-histone lysine methylation in response to DNA damage | 期刊论文 | Yongcan Chen();Wei-Guo Zhu() |
| 37 | NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2 | 期刊论文 | Xiaofeng Liu();Yuqin Tan;Chunfeng Zhang;Ying Zhang;Liangliang Zhang;Pengwei Ren;Hongkui Deng;Jianyuan Luo;Yang Ke;Xiaojuan Du() |
| 38 | Hyaluronic Acid-Coated Silver Nanoparticles As a Nanoplatform for in Vivo Imaging Applications | 期刊论文 | Zhang Xin();Yao Meinan;Chen Muhua;Li Liqiang;Dong Chengyan;Hou Yi;Zhao Huiyun;Jia Bing();Wang Fan() |
| 39 | Anti-tumor Effect of Integrin Targeted Lu-177-3PRGD(2) and Combined Therapy with Endostar | 期刊论文 | Shi Jiyun;Fan Di;Dong Chengyan;Liu Hao;Jia Bing;Zhao Huiyun;Jin Xiaona;Liu Zhaofei;Li Fang;Wang Fan |
| 40 | Association of Genetic Polymorphisms in CDH1 and CTNNB1 with Breast Cancer Susceptibility and Patients' Prognosis among Chinese Han Women | 期刊论文 | 贾玉棉;解云涛;王亚军;韩继媛;田新霞;方伟岗 |
| 41 | Trx1/TrxR1 system regulates post-selected DP thymocytes survival by modulating ASK1-JNK/p38 MAPK activities | 期刊论文 | Jin Rong;Gao Yuhan;Zhang Shusong;Teng Fei;Xu Xi;Aili Abudureyimujiang;Wang Yuqing;Sun Xiuyuan;Pang Xuewen;Ge Qing;Zhang Yu |
| 42 | Genome-wide analysis of Epstein-Barr virus (EBV) isolated from EBV-associated gastric carcinoma (EBVaGC) | 期刊论文 | Liu Ying;Yang Wenjun;Pan Yaqi;Lu Zheming;Ke Yang |
| 43 | SoftPanel: a website for grouping diseases and related disorders for generation of customized panels | 期刊论文 | Wang Likun();Zhang Cong();Watkins Johnathan;Jin Yan;McNutt Michael;Yin Yuxin() |
| 44 | miR-17 promotes expansion and adhesion of human cord blood CD34(+) cells in vitro | 期刊论文 | Hu, Mengyu|Zou, Junhua|Yin, Yuxin|Luo, Jianyuan| |
| 45 | PET Imaging of Neovascularization with Ga-68-3PRGD(2) for Assessing Tumor Early Response to Endostar Antiangiogenic Therapy | 期刊论文 | Liu X|Fan D|Sun Y|Wang fan| |
| 46 | Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology | 期刊论文 | Pan, Yaqi|Gao, Yunong|Lu, Zheming|Ke, Yang| |
| 47 | ATM-mediated KDM2A phosphorylation is required for the DNA damage repair | 期刊论文 | Cao Lin-Lin;Wei Fuzheng;Du Yipeng;Song Boyan;Wang Donglai;Shen Changchun;Lu Xiaopeng;Cao Ziyang;Yang Qiaoyan;Gao Yan;Wang Lina;Zhao Ying;Wang Haiying;Yang Yang;Zhu Wei-Guo |
| 48 | The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2 | 期刊论文 | Lu Shaoli();Yang Yang()();Du Yipeng;Cao Lin-lin;Li Meiting;Shen Changchun;Hou Tianyun;Zhao Ying;Wang Haiying;Deng Dajun;Wang Lina;He Qihua;Zhu Wei-Guo() |
| 49 | Tc-99m-HisoDGR as a Potential SPECT Probe for Orthotopic Glioma Detection via Targeting of Integrin alpha(5)beta(1) | 期刊论文 | Zhao Haitao();Gao Hannan;Zhai Luoping;Liu Xujie;Jia Bing;Shi Jiyun();Wang Fan() |
| 50 | MiR-509-3-5p causes aberrant mitosis and anti-proliferative effect by suppression of PLK1 in human lung cancer A549 cells | 期刊论文 | Xian-Hui Wang();Yao Lu();Jing-Jing Liang;Ji-Xiang Cao;Ya-Qiong Jin;Guo-Shun An;Ju-Hua Ni;Hong-Ti Jia;Shu-Yan Li() |
| 51 | Elevated HOXB9 expression promotes differentiation and predicts a favourable outcome in colon adenocarcinoma patients | 期刊论文 | Zhan J.();Niu M.;Wang P.;Zhu X.;Li S.;Song J.;He H.;Wang Y.;Xue L.;Fang W.();Zhang H.() |
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