缺血性心脏病防治的基础和临床研究

81225001
2012
H0205.冠状动脉性心脏病
陶凌
国家杰出青年科学基金
教授
中国人民解放军第四军医大学
200万元
硫氧还蛋白;脂联素;一氧化氮;细胞凋亡;心脏保护
2013-01至2016-12
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Increased myocardial ischemia-reperfusion injury in renal failure involves cardiac adiponectin signal deficiency 期刊论文 潘卫军;陈文涛;王璠
2 Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway 期刊论文 Xin C.;Liu J.;Zhang J.;Zhu D.;Wang H.;Xiong L.;Lee Y.;Ye J.;Lian K.;Xu C.;Zhang L.;Wang Q.;Liu Y.;Tao L.
3 Irisin通过激活AMPK促进小鼠骨骼肌细胞脂肪酸氧化 期刊论文 辛超;刘毅;朱迪;许倡涛;陶凌
4 脂联素抑制炎症小体NLRP3表达减轻高糖高脂诱导内皮细胞损伤 期刊论文 辛超|李燕|刘毅|陶凌|
5 Branched Chain Amino Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and Inhibiting Hepatic Autophagy. 期刊论文 Zhang, Ling|Lau, Wayne Bond|Ma, Xinliang|Tao, Ling|
6 Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1 alpha signaling contributing to increased vulnerability in diabetic heart 期刊论文 Yan Wenjun;Zhang Haifeng;Liu Peilin;Wang Han;Liu Jingyi;Gao Chao;Liu Yi;Lian Kun;Yang Lu;Sun Lu;Guo Yunping;Zhang Lijian;Dong Ling;Lau Wayne Bond;Gao Erhe;Gao Feng;Xiong Lize;Wang Haichang;Qu Yan;Tao Ling
7 Cardiac-derived adiponectin induced by long-term insulin treatment ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic mice via AMPK signaling 期刊论文 Li, Weijie|Lau, Wayne Bond|Zhang, Haifeng|Tao, Ling|
8 TNF-alpha antagonism ameliorates myocardial ischemia-reperfusion injury in mice by upregulating adiponectin 期刊论文 Gao Chao;Liu Yi;Yu Qiujun;Yang Qiang;Li Bing;Sun Lu;Yan Wenjun;Cai Xiaoqing;Gao Erhe;Xiong Lize;Wang Haichang;Tao Ling
9 Resveratrol Cardioprotection Against Myocardial Ischemia/Reperfusion Injury Involves Upregulation of Adiponectin Levels and Multimerization in Type 2 Diabetic Mice. 期刊论文 Liu, Yi|Gao, Chao|Sun, Lu|Tao, Ling|
10 TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury 期刊论文 Liu Yi;Lian Kun;Zhang Lijian;Wang Rutao;Yi Fu;Gao Chao;Xin Chao;Zhu Di;Li Yan;Yan Wenjun;Xiong Lize;Gao Erhe;Wang Haichang;Tao Ling
11 Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction 期刊论文 Fuyang Zhang;Yunlong Xia;Wenjun Yan;Haoqiang Zhang;Fen Zhou;Shihao Zhao;Wei Wang;Di Zhu;Chao Xin;Yan Lee;Ling Zhang;Yuan He;Erhe Gao;Ling Tao
12 血清Irisin浓度与颈动脉内中膜厚度的相关性 期刊论文 郭显;刘毅;张静隆;李燕;李珊;吕安林;陶凌
13 鸢尾素通过抑制氧化应激减轻高糖/高脂诱导的人脐静脉内皮细胞损伤 期刊论文 朱迪;张小天;刘毅;辛超;张静隆;王海昌;陶凌
14 Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice 期刊论文 Lian Kun;Du Chaosheng;Liu Yi;Zhu Di;Yan Wenjun;Zhang Haifeng;Hong Zhibo;Liu Peilin;Zhang Lijian;Pei Haifeng;Zhang Jinglong;Gao Chao;Xin Chao;Cheng Hexiang;Xiong Lize;Tao Ling
15 Notch1 cardioprotection in myocardial ischemia/reperfusion involves reduction of oxidative/nitrative stress 期刊论文 Pei Haifeng;Yu Qiujun;Xue Qiang;Guo Yunping;Sun Lu;Hong Zhibo;Han Hua;Gao Erhe;Qu Yan;Tao Ling
16 第十届陕西青年科技奖 奖励 李蓉()()
17 长江学者特聘教授 奖励 杨茂君()
18 生长分化因子11在白色脂肪细胞棕色化中的作用研究 期刊论文 闫柄文;刘毅;裴海峰;王姍;张玲;陶凌
19 Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses 期刊论文 Zhu Di();Wang Haichang();Zhang Jinglong();Zhang Xiaotian;Xin Chao;Zhang Fuyang;Lee Yan;Zhang Ling;Lian Kun;Yan Wenjun;Ma Xinliang;Liu Yi();Tao Ling()
20 Reduction Levels and the Effects of High-Molecular-Weight Adiponectin via AMPK/eNOS in Chinese Type 2 Diabetes 期刊论文 Lian K();Guo X();Huang Q;Tan Z;Xia C;Wang R;Yi F;Li W;Liu J;Li Y;Guo S;Wang H;Ji Q();Tao L()
21 陕西省中青年科技创新领军人才 奖励 漆红兰
22 支链氨基酸促进高脂诱导的小鼠肝脏胰岛素抵抗 期刊论文 郭雄|黄冲|刘朝中|陶凌|
23 陕西青年科技标兵 奖励 李印实
24 BCKA down-regulates mTORC2-Akt signal and enhances apoptosis susceptibility in cardiomyocytes. 期刊论文 Zhang, Jinglong|Xie, Huaning|An, Rui|Tao, Ling|
25 BCAA代谢障碍在儿茶酚胺诱导心肌细胞毒性中作用 期刊论文 闫文俊|李燕|张玲|陶凌|
26 Defective branched chain amino acid catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction. 期刊论文 Wang W;Zhang F;Xia Y;Zhao S;Yan W;Wang H;Lee Y;Li C;Zhang L;Lian K;Gao E;Cheng H;Tao L
27 军队医疗成果一等奖 奖励 貌盼勇;宋立华;李进;王汉中;白冰珂;刘鸿凌;辛绍杰;端青;左庭婷
28 T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity. 期刊论文 Summer, Ross|Lau, Wayne Bond|Wang, Yajing|Ma, Xinliang|
29 Mitochondrial translocation of Nur77 induced by ROS contributed to cardiomyocyte apoptosis in metabolic syndrome 期刊论文 Xu Aibin;Liu Jingyi;Liu Peilin;Jia Min;Wang Han;Tao Ling
30 Adiponectin regulates SR Ca2+ cycling following ischemia/reperfusion via sphingosine 1-phosphate-CaMKII signaling in mice 期刊论文 Yan Wenjun;Zhang Fuyang;Zhang Ronghuai;Zhang Xing;Wang Yanru;Zhou Fen;Xia Yunlong;Liu Peilin;Gao Chao;Wang Han;Zhang Lijian;Zhou Jingjun;Gao Feng;Gao Erhe;Koch Walter J.;Wang Haichang;Cheng Heping;Qu Yan;Tao Ling
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