自噬调节在软骨功能障碍相关疾病的作用机制研究

81222026
2012
H0608.骨、关节、软组织退行性病变
武淑芳
优秀青年科学基金项目
教授
西安交通大学
100万元
软骨退行性变;软骨功能稳态;细胞自噬
2013-01至2015-12
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Autophagic Dysfunction is Improved by Intermittent Administration of Osteocalcin in Obese Mice. 期刊论文 Zhou B Li H Liu J Xu L Guo Q Zang W;Sun H;Wu S (通讯作者，西安交通大学)
2 The Reciprocal Interaction between Autophagic Dysfunction and ER stress in Adipose Insulin Resistance 期刊论文 Li H, Zhou B, Xu L, Liu J, Zang W, Wu S*|Sun H*(通讯作者)|
3 Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner. 期刊论文 Li H，Zhou B，Liu J，Li F，Li Y，Kang X;Sun H;Wu S （通讯作者，西安交通大学）
4 Circulating PGRN Is Significantly Associated With Systemic Insulin Sensitivity and Autophagic Activity in Metabolic Syndrome. 期刊论文 Liu J|Zang W|Wu S|Sun H|
5 Osteocalcin Reverses Endoplasmic Reticulum Stress and Improves Impaired Insulin Sensitivity Secondary to Diet-induced Obesity Through Nuclear factor-kB Signaling pathway 期刊论文 Bo Zhou, Huixia Li, Lin Xu, Weijin Zang|Shufang Wu (共同通讯作者，西安交通大学）|Hongzhi Sun|
6 Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 期刊论文 Wu S （西安交通大学）|Grunwald T, Kharitonenkov A, Dam J, Jockers R, De Luca|
7 Insulin-like growth factor independent effects of growth hormone on growth plate chondrogenesis and longitudinal bone growth. 期刊论文 Wu S (西安交通大学);Yang W;De Luca F
8 PGRN Induces Impaired Insulin Sensitivity and Defective Autophagy in Hepatic Insulin Resistance 期刊论文 Liu Jiali;Li Huixia;Zhou Bo;Xu Lin;Kang Xiaomin;Yang Wei;Wu Shufang;Sun Hongzhi
9 Intermittent injections of osteocalcin reverse autophagic dysfunction and endoplasmic reticulum stress resulting from diet-induced obesity in the vascular tissue via the NF-KB p65-dependent mechanism 期刊论文 Bo Zhou, Huixia Li, Jiali Liu, Lin Xu, Weijin Zang|Shufang Wu, Hongzhi Sun（西安交通大学）|
10 Increased expression of Fibroblast Growth Factor 21 (FGF21) during chronic undernutrition causes Growth Hormone insensitivity in chondrocytes by inducing leptin receptor overlapping transcript (LEPROT) and leptin receptor overlapping transcript-like 期刊论文 Wu S (西安交通大学)|Grunwald T, Kharitonenkov A, Dam J, Jockers R, De Luca F|
11 Circulating PGRN Is Significantly Associated With Systemic Insulin Sensitivity and Autophagic Activity in Metabolic Syndrome 期刊论文 Li Huixia;Zhou Bo;Xu Lin;Liu Jiali;Zang Weijin;Wu Shufang;Sun Hongzhi
12 Progranulin Induces Adipose Insulin Resistance and Autophagic Imbalance via TNFR1 in Mice. 期刊论文 Zhou B，Li H，Liu J，Xu L，Guo Q，Sun H;Wu S (通讯作者，西安交通大学)
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