代谢性核受体与胰岛素抵抗

30890043
2008
H0220.循环系统疾病研究新技术与新方法
李小英
重大项目
教授
上海交通大学
180万元
胰岛素抵抗；胆汁酸受体；类固醇共激活因子；代谢性核受体
2009-01至2012-12
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. 期刊论文 郭非凡|
2 ATF4 regulates lipid metabolism and thermogenesis. 期刊论文
3 Glucocorticoids promote hepatic cholestasis in mice by inhibiting the transcriptional activity of the farnesoid x receptor 期刊论文 Yan Lu;Zhijian Zhang;Xuelian Xiong;Xiaolin Wang;Jin Li;Guojun Shi;Jian Yang;Xianfeng Zhang;Huijie Zhang;Jie Hong;Xuefeng Xia;Guang Ning;Xiaoying Li
4 Gastric mTOR signaling regulates ghrelin production and food intake 期刊论文 张炜真|
5 Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue. 期刊论文 郭非凡|
6 mTOR-dependent modulation of gastric nesfatin-1/NUCB2. 期刊论文 李自茹;许戈阳;李茵;赵晶;Michael W. Mulholland;张炜真
7 Yin Yang 1 promotes hepatic steatosis through repression of farnesoid X receptor in obese mice. 期刊论文 Lu Y;Ma Z;Zhang Z;Xiong X;Wang X;Zhang H;Shi G;Xia X;Ning Guang;Li X.
8 DAX1 suppresses FXR transactivity as a novel co-repressor 期刊论文 Li Jin;Lu Yan;Liu Ruya;Xiong Xuelian;Zhang Zhijian;Zhang Xianfeng;Ning Guang;Li Xiaoying
9 ATF4 deficiency protects mice from high-carbohydrate diet-induced liver steatosis. 期刊论文 郭非凡|
10 Regulation of gastric hormone production by rapamycin 期刊论文 张炜真|
11 mTOR and the differentiation of mesenchymal stem cells. 期刊论文 张炜真|
12 Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT. 期刊论文 郭非凡|
13 S6K1 in the central nervous system regulates energy expenditure via MC4R/corticotrophin -releasing hormone pathways in response to deprivation of an essential amino acid. 期刊论文 Xia T;Cheng Y;Zhang Q;Guo F
14 Ghrelin fluctuation, what determines its production? 期刊论文 Li, Yin|Zhang, Weizhen|An, Wenjiao|Yin, Xuefeng|Xu, Geyang|
15 Ghrelin contributes to derangements of glucose metabolism induced by rapamycin in mice. 期刊论文 Guan, Youfei|Tang, Chaoshu|Mulholland, Michael|Zhang, Weizhen|
16 Leucine deprivation stimulates fat loss via increasing corticotrophin releasing hormone (CRH) expression in the hypothalamus and activating sympathetic nervous system (SNS). 期刊论文 郭非凡|
17 Modulation of ghrelin O acyltransferase expression in pancreatic islets. 期刊论文 张炜真|
18 Effects of ATF4 on PGC1 expression in brown adipose tissue and metabolic responses to cold stress. 期刊论文 郭非凡|
19 Yin Yang 1 Promotes Hepatic Gluconeogenesis Through Upregulation of Glucocorticoid Receptor 期刊论文 Lu Y;Xiong X;Wang X;Zhang Z;Li J;Shi G;Yang J;Zhang H;Ning G;Li X
20 Deficiency in Pulmonary Surfactant Proteins in Mice with FABP4-Cre MediatedKnockout of TSC1 Gene. 期刊论文 张炜真|
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