H5N1禽流感病毒的表型多样性的分子变异机制研究
30825032
2008
C1806.兽医传染病学
陈化兰
国家杰出青年科学基金
研究员
中国农业科学院哈尔滨兽医研究所
200万元
禽流感；H5N1；表型多样性；分子机制
2009-01至2012-12
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | The PA Protein Directly Contributes to the Virulence of H5N1 Avian Influenza Viruses in Domestic Ducks | 期刊论文 | Song Jiasheng;Feng Huapeng;Xu Jing;Zhao Dongming;Shi Jianzhong;Li Yanbing;Deng Guohua;Jiang Yongping;Li Xuyong;Zhu Pengyang;Guan Yuntao;Bu Zhigao;Kawaoka Yoshihiro;Chen Hualan |
| 2 | Phylogenetic and Pathogenic Analyses of Avian Influenza A H5N1 Viruses Isolated from Poultry in Vietnam | 期刊论文 | Dongming Zhao;Libin Liang;Yanbing Li;Yongping Jiang;Liling Liu;Hualan Chen |
| 3 | Continued Evolution of H5N1 Influenza Viruses in Wild Birds, Domestic Poultry, and Humans in China from 2004 to 2009 | 期刊论文 | Li Yanbing;Shi Jianzhong;Zhong Gongxun;Deng Guohua;Tian Guobin;Ge Jinying;Zeng Xianying;Song Jiasheng;Zhao Dongming;Liu Liling;Jiang Yongping;Guan Yuntao;Bu Zhigao;Chen Hualan |
| 4 | Characterization of Immune Responses Induced by Immunization with the HA DNA Vaccines of Two Antigenically Distinctive H5N1 HPAIV Isolates | 期刊论文 | Yulong Gao|Zhiyuan Wen|Ke Dong|Gongxun Zhong|Xiaomei Wang|Zhigao Bu|Hualan Chen|Ling Ye|Chinglai Yang| |
| 5 | Reassortant H1N1 influenza virus vaccines protect pigs against pandemic H1N1 influenza virus and H1N2 swine influenza virus challenge | 期刊论文 | Yang, Huanliang|Chen, Hualan|Chen, Yan|Shi, Jianzhong|Guo, Jing|Xin, Xiaoguang|Zhang, Jian|Wang, Dayan|Shu, Yuelong|Qiao, Chuanling| |
| 6 | New Avian Influenza Virus (H5N1) in Wild Birds, Qinghai, China | 期刊论文 | Li Yanbing;Liu Liling;Zhang Yi;Duan Zhenhua;Tian Guobin;Zeng Xianying;Shi Jianzhong;Zhang Licheng;Chen Hualan |
| 7 | H5N1亚型禽流感病毒进化、跨宿主感染及致病力分子机制研究 | 奖励 | 陈化兰 |
| 8 | Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice | 期刊论文 | Fan Shufang;Deng Guohua;Song Jiasheng;Tian Guobin;Suo Yongbing;Jiang Yongping;Guan Yuntao;Bu Zhigao;Kawaola Yoshihiro;Chen Hualan |
| 9 | Proteomic analysis of the lungs of mice infected with different pathotypes of H5N1 avian influenza viruses | 期刊论文 | Zhao Dongming;Liang Libin;Li Yanbing;Liu Liling;Guan Yuntao;Jiang Yongping;Chen Hualan |
| 10 | 禽流感（H5+H9）二价灭活疫苗 | 奖励 | 陈化兰| |
| 11 | Identification of Amino Acids in HA and PB2 Critical for the Transmission of H5N1 Avian Influenza Viruses in a Mammalian Host | 期刊论文 | Gao Yuwei;Zhang Ying;Shinya Kyoko;Deng Guohua;Jiang Yongping;Li Zejun;Guan Yuntao;Tian Guobin;Li Yanbing;Shi Jianzhong;Liu Liling;Zeng Xianying;Bu Zhigao;Xia Xianzhu;Kawaoka Yoshihiro;Chen Hualan |
| 12 | Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice | 期刊论文 | Jianzhong Shi|Zhigao Bu|Hualan Chen|Zhiyuan Wen|Jing Guo|Ying Zhang|Guohua Deng|Yuelong Shu|Dayan Wang|Yongping Jiang|Yoshihiro Kawaoka| |
| 13 | Key Molecular Factors in Hemagglutinin and PB2 Contribute to Efficient Transmission of the 2009 H1N1 Pandemic Influenza Virus | 期刊论文 | Zhang, Ying|Kawaoka, Yoshihiro|Bu, Zhigao|Chen, Hualan|Zhang, Qianyi|Gao, Yuwei|He, Xijun|Kong, Huihui|Jiang, Yongping|Guan, Yuntao|Xia, Xianzhu|Shu, Yuelong| |
| 14 | Human Infection from Avian-like Influenza A (H1N1) Viruses in Pigs, China | 期刊论文 | Yang Huanliang;Qiao Chuanling;Tang Xu;Chen Yan;Xin Xiaoguang;Chen Hualan |
| 15 | A Duck Enteritis Virus-Vectored Bivalent Live Vaccine Provides Fast and Complete Protection against H5N1 Avian Influenza Virus Infection in Ducks | 期刊论文 | Liu Jinxiong;Chen Pucheng;Jiang Yongping;Wu Li;Zeng Xianying;Tian Guobin;Ge Jinying;Kawaoka Yoshihiro;Bu Zhigao;Chen Hualan |
| 16 | Integrated Clinical, Pathologic, Virologic, and Transcriptomic Analysis of H5N1 Influenza Virus-Induced Viral Pneumonia in the Rhesus Macaque | 期刊论文 | Shinya Kyoko;Gao Yuwei;Cilloniz Cristian;Suzuki Yasuhiro;Fujie Masahiro;Deng Guohua;Zhu Qiyun;Fan Shufang;Makino Akiko;Muramoto Yukiko;Fukuyama Satoshi;Tamura Daisuke;Noda Takeshi;Eisfeld Arnie J.;Katze Michael G.;Chen Hualan;Kawaoka Yoshihiro |
| 17 | Co-circulation of pandemic 2009 H1N1, classical swine H1N1 and avian-like swine H1N1 influenza viruses in pigs in China | 期刊论文 | Yan Chen;Jian Zhang;Chuanling Qiao;Huanliang Yang;Ying Zhang;Xiaoguang Xin;Hualan Chen |
| 18 | Recombinant duck enteritis virus works as a single-dose vaccine in broilers providing rapid protection against H5N1 influenza infection | 期刊论文 | Liu Jinxiong;Chen Pucheng;Jiang Yongping;Deng Guohua;Shi Jianzhong;Wu Li;Lin Yuan;Bu Zhigao;Chen Hualan |
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