放射生物学
30825011
2008
H29.放射医学
周平坤
国家杰出青年科学基金
研究员
中国人民解放军军事科学院军事医学研究院
200万元
DNA损伤修复；细胞遗传；辐射防护；空间辐射；低剂量辐射
2009-01至2012-12
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Alteration of transcriptional profile in human bronchial epithelial cells induced by cigarette smoke condensate | 期刊论文 | Hu YC;Yang ZH;Zhong KJ;Niu LJ;Pan XJ;Wu D;Sun XJ;Zhou PK;Zhu MX;Huo YY. |
| 2 | 香兰素衍生物VND3207对γ射线照射人淋巴母细胞基因组损伤和凋亡的保护作用 | 期刊论文 | 黄锐;贺性鹏;徐勤枝;王豫;黄波;周平坤 |
| 3 | VND3207对γ射线所致细胞DNA损伤和凋亡的防护作用 | 会议论文 | 黄锐;贺性鹏;徐勤枝;王豫;黄波;周平坤 |
| 4 | c-Myc蛋白与DNA-PKcs作用位点的鉴定 | 期刊论文 | 尚增甫;徐勤枝;安静;王豫;周平坤 |
| 5 | Interaction between viral proteins and hosts and its disturbance in the cellular responses to ionizing radiation | 期刊论文 | Zhou Pk;Sun Y;An J |
| 6 | Induced expression of the IER5 genes by γ-ray irradiation and its involvement in cell cycle checkpoint control and survival | 期刊论文 | Ding KK;Shang ZF;Hao C;Xu QZ;Shen JJ;Yang CJ;Xie YH;Qiao C;Wang Y;Xu LL;Zhou PK. |
| 7 | 4E-BP1 participates in maintaining the spindle integrity and genomic stability via interacting with PLK1. | 期刊论文 | Shang ZF;Yu L;Li B;Tu WZ;Wang Y;Liu XD;Guan H;Huang B;Rang WQ;Zhou PK. |
| 8 | DNA-PKcs单链抗体DPK3-scFv的原核表达纯化及生物学作用研究 | 期刊论文 | 邢小翠;周丽君;尚增甫;杨天一;李兵;王豫;刘晓丹;郑红;汪思应;周平坤;XING Xiao-cui;ZHOU Li-jun;SHANG Zeng-fu;YANG Tian-yi;Li Bing;WANG Yu;LIU Xiao-dan;ZHENG Hong;WANG Si-ying;ZHOU Ping-kun |
| 9 | Proteomic analysis reveals the radiosensitization of vanillin derivative bromovanin by targeting G2/M checkpoint and mitotic catastrophe. | 会议论文 | 周平坤 |
| 10 | 质子剂量和DNA浓度对DNA损伤的影响 | 期刊论文 | 隋丽;王潇;周平坤;倪嵋楠;孔福全;杨磊;刘建成;赵葵;SUI Li1 2 WANG Xiao1 ZHOU Pingkun2 NI Meinan1 KONG Fuquan1 YANG Lei1 LIU Jiancheng1 ZHAO Kui1 1(China Institute of Atomic Energy Beijing 102413 China) 2(Beijing Institute of Radiation Medicine Beijing 100850 China) |
| 11 | 转录反式激活因子对DNA-PKcs启动子的调控作用 | 期刊论文 | 杨天一;张士猛;秦夏;李兵;刘晓丹;周平坤;YANG Tian-yi;ZHANG Shi-meng;QIN xia;LI Bing;LIU Xiao-dan;ZHOU Ping-kun |
| 12 | Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo | 期刊论文 | Xiu-Jie Pan|Yu Wang|Yu-Xia Wang|Zhi-Hua Yang|Qin-Zhi Xu|Mao-Xiang Zhu|Ping-Kun Zhou|Li Du|Li-Jun Zhou| |
| 13 | 电离辐射非靶效应及ICRP的相关评议 | 期刊论文 | 周平坤 |
| 14 | 60Co γ射线诱导正常人淋巴母细胞XPCmRNA表达的剂量相关性研究 | 期刊论文 | 刘晓丹;张士猛;李兵;樊嵘;陈英;周平坤;LIU Xiao-dan;ZHANG Shi-meng;Ll Bing;FAN Rong;CHEN Ying;ZHOU Ping-kun |
| 15 | Polo样激酶1在细胞周期及细胞周期监测点中的功能 | 期刊论文 | 尚增甫;徐勤枝;周平坤 |
| 16 | Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated Chk2 phosphorylation in response to DNA damage | 期刊论文 | Yu Wang|Ping-Kun Zhou|Shi-Meng Zhang|Qin-Zhi Xu|Xiao-Dan Liu|Zeng-Fu Shang|Bo Huang|Ron Fan| |
| 17 | 同源重组修复基因RAD51可提高PTEN缺失细胞基因组稳定性 | 期刊论文 | 陈忠民;徐勤枝;胡迎春;霍艳英;周平坤;吴德昌;CHEN Zhong-min;XU Qin-zhi;HU Ying-chun;HUO Yan-ying;ZHOU Ping-kun;WU De-chang |
| 18 | HIV-1 Tat regulates cyclin B1 by promoting both expression and degradation | 期刊论文 | Zhang SM;Sun Y;Fan R;Xu QZ;Liu XD;Zhang X;Wang Y;Zhou PK. |
| 19 | 60Co γ射线诱导正常人淋巴母细胞PIG3基因mRNA表达的剂量相关性研究 | 期刊论文 | 刘晓丹;张士猛;李兵;尚增甫;徐勤枝;周平坤;LIU Xiao-dan;ZHANG Shi-meng;LI Bing;SHANG Zen-pu;XU Qin-zhi;ZHOU Ping-kun |
| 20 | 6-溴异香兰素对HeLa细胞的增殖抑制及放射增敏作用 | 期刊论文 | 周平坤|徐勤枝|王豫|张士猛|刘晓丹|王林|张博| |
| 21 | Radon-induced alterations in micro-RNA expression profiles in transformed BEAS2B cells. | 期刊论文 | Cui Feng-Mei;Li Jian-Xiang;Chen Qiu;Du Hou-Bin;Zhang Shu-Yu;Nie Ji-Hua;Cao Jian-Ping;Zhou Ping-Kun;Hei Tom K;Tong Jian |
| 22 | p53-dependent upregulation of PIG3 transcription by -ray irradiation and its interaction with KAP 1 in responding to DNA damage. | 期刊论文 | Qin X;Zhang SM;Li B;Liu XD;He XP;Shang ZF;Xu QZ;Zhao ZQ;Ye QN;Zhou PK. |
| 23 | 香兰素衍生物VND3207对α粒子辐射诱发人成纤维细胞基因组DNA损伤的防护研究 | 期刊论文 | 陈倩倩;汪黎;尚增甫;刘晓丹;王豫;郑红;汪思应;周平坤 |
| 24 | Seventeen-year follow-up study on chromosomal aberrations in five victims accidentally exposed to several Gy of 60Co g-rays | 期刊论文 | Chen Y|Jin CZ|Zhang XQ|Ge SL|Zhang ZY|Xu H|Liu XL|Wu DC|Zhou PK.| |
| 25 | DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression | 期刊论文 | An Jing;Huang Yue-Cheng;Xu Qing-Zhi;Zhou Li-Jun;Shang Zeng-Fu;Huang Bo;Wang Yu;Liu Xiao-Dan;Wu De-Chang;Zhou Ping-Kun |
| 26 | 14MeV单能中子致DNA链断裂及相应防护研究 | 期刊论文 | 隋丽;王潇;周平坤;倪嵋楠;孔福全;杨磊;赵葵;陈红涛;SUI Li;WANG Xiao;ZHOU Ping-kun;NI Mei-nan;KONG Fu-quan;YANG Lei;ZHAO Kui;CHEN Hong-tao |
| 27 | 香兰素衍生物VND3207对不同LET辐射致质粒DNA损伤的防护作用 | 期刊论文 | LIU Xiao-dan|刘晓丹|张士猛|XU Qin-zhi|徐勤枝|王潇|徐辉辉|WANG Xiao|关华|周平坤|ZHOU Ping-kun|WANG Yu|SUI Li|WANG Li|隋丽|王豫|XU Hui-hui|GUAN Hua|汪黎|ZHANG Shi-meng| |
| 28 | Tat蛋白与Plk1相互作用位点的鉴定 | 期刊论文 | 杨天一;张士猛;尚增甫;刘晓丹;周平坤;YANG Tian-yi;ZHANG Shi-meng;SHANG Zeng-fu;LIU Xiao-dan;ZHOU Ping-kun |
| 29 | DNA-PKcs在ATM缺陷细胞中调节DNA损伤周期检查点反应机制的研究 | 会议论文 | 黄波;尚增甫;徐勤枝;张士猛;刘晓丹;王豫;周平坤 |
| 30 | FOXO3a介导PTEN对DNA修复基因RAD51表达的调节作用 | 期刊论文 | 陈忠民;胡迎春;徐勤枝;周平坤;吴德昌;CHEN Zhong-min;HU Ying-chun;XU Qin-zhi;ZHOU Ping-kun;WU De-chang |
| 31 | Proteomic profiling revealed the functional networks associated with mitotic catastrophe of HepG2 hepatoma cells induced by 6-bromine-5-hydroxy-4-methoxybenzaldehyde. | 期刊论文 | Zhang B;Huang B;Guan H;Zhang SM;Xu QZ;He XP;Liu XD;Wang Y;Shang ZF;Zhou PK. |
| 32 | PTEN通过抑制PI3K-AKT信号通路上调Rad51基因的表达 | 期刊论文 | 陈忠民;胡迎春;莫琳;霍艳英;徐勤枝;周平坤;吴德昌;CHEN Zhong-Min1) HU Ying-Chun1) MO Lin2) HUO Yan-Ying1) XU Qin-Zhi1) ZHOU Ping-Kun1) WU De-Chang1)(1) Beijing Institute of Radiation Medicine Beijing 100850 China;2) Chongqing Medical University Chongqing 400016 China) |
| 33 | DNA Damage, Signaling and Repair: Protecting genomic integrity and reducing the risk of human disease. | 期刊论文 | Zhou Pk |
| 34 | V(D)J重组与DNA非同源末端连接 | 期刊论文 | 杜丽;周平坤 |
| 35 | Anticancer Effect of Vanillin Derivative BVAN08 by Inactivating DNA-PKcs and Inducing DNA Double-Strand Breaks | 会议论文 | 周平坤 |
| 36 | Gamma-ray Up-regulated Holocarboxylase Synthetase Gene. | 期刊论文 | Ding K;Yang C;Shen J;Xu L;Li Y;Zhou P;Zeng Y. |
| 37 | 模拟空间辐射生物学效应的研究进展 | 期刊论文 | 周平坤 |
| 38 | 贫铀的健康影响研究进展 | 期刊论文 | 朱茂祥;周平坤 |
| 39 | TAB182对电离辐射诱发细胞周期G2/M阻滞的调节作用 | 期刊论文 | 邹联洪|邹联洪|徐勤枝|徐勤枝|刘晓丹|刘晓丹|王豫|王豫|李兵|李兵|钟才高|钟才高|周平坤|周平坤|ZOU Lian-Hong1),2),XU Qin-Zhi2),LIU Xiao-Dan2),WAN|ZOU Lian-Hong1),2),XU Qin-Zhi2),LIU Xiao-Dan2),WAN|2) Department of Radiation Toxicology and Oncology|2) Department of Radiation Toxicology and Oncology |
| 40 | HIV-1 Tat impairs cell cycle control by targeting the Tip60, Plk1 and cyclin B1 ternary complex. | 期刊论文 | Zhang SM;Song M;Yang TY;Fan R;Liu XD;Zhou PK. |
| 41 | 一种基于GFP分子荧光显示的检测大尺度染色质松弛技术的建立 | 期刊论文 | 秦夏;张士猛;徐勤枝;叶棋浓;周平坤;QIN Xia1) ZHANG Shi-Meng1) XU Qin-Zhi1) YE Qi-Nong2) ZHOU Ping-Kun1)(1) Beijing Institute of Radiation Medicine Beijing 100850 China;2) Beijing Institute of Biotechnology Beijing 100071 China) |
| 42 | Splitting of cell clumps in cytokinesis-blocked micronucleus images: application to improve the recognition ability of binucleated lymphocytes | 期刊论文 | Yan XK|Zhang N|Chen Y|Du J|Cao ZS|Zhou PK| |
| 43 | Anticancer effect of vanillin derivative bvan08 by inactivating dna-pkcs and inducing dna double-strand breaks | 奖励 | 张博 |
| 44 | 与细胞周期G2/M期进程相关的H2AX磷酸化 | 期刊论文 | 涂文志;尚增甫;李兵;刘晓丹;王豫;徐勤枝;让蔚清;周平坤;TU Wen-Zhi1) 2) SHANG Zeng-Fu2) LI Bing2) LIU Xiao-Dan2) WANG Yu2) XU Qin-Zhi2) RANG Wei-Qing1) ZHOU Ping-Kun1) 2) (1) Institute of Environmental Medicine and Radiation Health School of Public Health University of South China Hengyang 421001 Hunan China;2) Institute of Radiation Medicine Academy of Military Medical Sciences PLA Beijing 100850 China) |
| 45 | Biological dose estimation for accidental supra-high dose gamma-ray exposure. | 期刊论文 | Chen Y;Yan XK;Du J;Wang ZD;Zhang XQ;Zeng FG;Zhou PK. |
| 46 | 不同LET辐射致DNA集簇性损伤的研究 | 期刊论文 | 周平坤|WANG Li|WANG Yu|刘晓丹|XU Hui-hui|SUI Li|徐辉辉|王豫|汪黎|XU Qin-zhi|ZHOU Ping-kun|WANG Xiao|王潇|徐勤枝|LIU Xiao-dan|隋丽| |
| 47 | Tip60基因沉默对细胞DNA双链断裂修复和辐射敏感性的影响 | 期刊论文 | 樊嵘;张士猛;刘晓丹;王豫;徐勤枝;周平坤;FAN Rong;ZHANG Shi-meng;LIU Xiao-dan;WANG Yu;XU Qin-zhi;ZHOU Ping-kun |
| 48 | 6-溴异香兰素诱发人宫颈癌上皮细胞纺锤体损伤及有丝分裂灾变死亡 | 期刊论文 | 张士猛|刘晓丹|周平坤|张博|徐勤枝|关华|王豫| |
| 49 | Strand-specific PCR of UV radiation-damaged genomic DNA revealed an essential role of DNA-PKcs in the transcription-coupled repair | 期刊论文 | An Jing;Yang Tianyi;Huang Yuecheng;Liu Feng;Sun Jingfen;Wang Yu;Xu Qingzhi;Wu Dechang;Zhou Pingkun |
| 50 | 香兰素衍生物BVAN08对人脑胶质瘤细胞的放射增敏作用及机制研究 | 期刊论文 | 王豫|刘晓丹|周平坤|徐勤枝|孙伟建|王树彬|张博| |
| 51 | 核辐射对人体的生物学危害及医学防护基本原则 | 期刊论文 | 周平坤;ZHOU Ping-kun(The Department of Radiation Toxicology and Risk Assessment Beijing Institute of Radiation Medicine) |
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