低氧获得性适应与遗传性适应的细胞分子机制和内源性促适应物质及干预

30393133
2003
C1105.整合生理学与整合生物学
杨黄恬
重大项目
研究员
中国科学院上海营养与健康研究所
150万元
损伤..
2003-10至2008-09
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Cardioprotective effect of intermittent hypoxia 会议论文
2 Postnatal Development in intermittent hypoxia enhances resistance to myocardial ischemia/reperfusion in male rats. 期刊论文
3 CaMK II 在间歇性低氧抗心肌缺血/再灌注损伤中的作用 会议论文
4 2003年健康科学研究所“GRAD”优秀研究报告奖 奖励
5 A Brief history of mountain medicine on the Qinghai-Tibetan plateau 会议论文
6 2004年中科院“地奥”二等奖 奖励
7 2007年中科院院长优秀奖 奖励
8 Clinical study of 55cases of high altitude heart disease in children in Qinghai. 会议论文
9 不同海拔地区人外周血白细胞端粒DNA长度与自由基变化研究 期刊论文
10 E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1. 期刊论文 Yang W-W;Wang Z-H;Zhu Y;Yang H-T
11 Preliminary study on alternation of home-keeping genes within neuron after hypoxia. 会议论文
12 Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury. 期刊论文 Ding HL;Zhu HF Dong JW Zhu WZ Yang WW Yang HT;Zhou ZN.
13 ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury. 期刊论文 Zhu HF Dong JW Zhu WZ Ding HL Zhou ZN.
14 荧光定时定量PCR检测端粒长度 期刊论文
15 Cardioprotection of intermittent hypoxia adaptation: regulation of Ca2+ homeostasis. 会议论文
16 Intermittent high altitude hypoxia protects the heart against lethal Ca2+ overload injury. 期刊论文
17 Activation of ?1B-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca2+ overload in cardiomyocytes. 期刊论文
18 钙稳态和间歇性低氧心肌保护作用。 会议论文
19 Intermittent hypoxia attenuates ischemia/reperfusion-induced apoptosis in rat heart via regulating Bcl-2/Bax expression 期刊论文
20 Changes of cardiac structure and function in pediatric patients with high altitude heart disease in Tibet. 会议论文
21 Progress of studying weight loss at high altitude and its potential application in patients with obesity. 会议论文
22 A study of heart structure in 1062 healthy children living at different altitudes. 会议论文
23 Intermittent Hypoxia: Cardioprotection against Ischemic Injury. 会议论文
24 Cloning and tissue expression of the three oxygen-binding andoxygen-transferring proteins in Pika at high altitude. 会议论文
25 脑红蛋白与高原低氧性脑保护 期刊论文
26 Intermittent hypoxia and cardioprotection 会议论文
27 Effects of different modes of intermittent hypoxia on ischemia/reperfusion injury in developing rat hearts. 期刊论文
28 间歇性低氧对缺血性心脏损伤的防治研究 专著 杨黄恬;周兆年;陈乐
29 2007年徕卡青年优秀论文三等奖 奖励
30 Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2/Bax expression 期刊论文
31 启动心脏内源性防御机制是抗心肌缺血和心力衰竭的新途径 会议论文 高鸿|杨黄恬|于卓|陆熙园|陈乐|王志华|
32 Intermittent hypoxia protects the rat heart against ischemia/reperfusion injury by activating protein kinase C. 期刊论文 Ding HL;Zhu HF Dong JW Zhu WZ Zhou ZN.
33 Preservation of the pHi during ischemia via PKC by intermittent hypoxia 期刊论文
34 Molecular cloning of hemoglobin alpha-chain gene from Pantholops hodgsonii, a hypoxic tolerance species. 期刊论文
35 低氧与心肌细胞凋亡 期刊论文
36 The SDS-page analysis in recombinants of hif-lalpha expressing in plateau pika. 会议论文
37 2007年第六届海峡两岸心血管科学研讨会青年优秀论文二等奖 奖励
38 Intermittent hypoxia and cardioprotection: mechanisms and therapeutic implication 会议论文
39 间歇性低氧适应的心脏保护 期刊论文 张翼;杨黄恬;周兆年
40 高原鼠兔低氧适应分子机制的研究进展 期刊论文 马兰;格日力
41 Effects of chronic intermittent hypoxia on the hemodynamics of systemic circulation in rats. 期刊论文
42 Role of dual-site phospholamban phosphorylation in intermittent hypoxia-induced cardioprotection against ischemia-reperfusion injury. 期刊论文 Xie Y;Zhu Y;Zhu WZ;Chen L;Zhou ZN;Yuan WJ;Yang HT
43 Tibetans retained innate ability resistance to acute hypoxia after long period of residing at sea lever 期刊论文
44 Cardiac protection by adaptation to intermittent hypoxia 会议论文
45 Tetrandrine relaxes the pulmonary artery in hypoxia. 会议论文
46 国家科学技术进步奖 奖励 程国栋;赖远明;马巍;吴青柏;牛富俊;俞祁浩;金会军;刘永智;盛煜;张建明;李东庆;温智;张明义;李国玉;喻文兵
47 线粒体：对抗缺血/再灌注内钙超载和收缩抑制的靶标 会议论文
48 Expression pattern of E2F6 in physical and chemical hypoxia-induced apoptosis. 期刊论文
49 2005年健康科学研究所 “GRAD”特别墙报奖 奖励
50 心肌缺血保护研究的新进展 会议论文
51 α1B－肾上腺素受体减轻心肌缺血/再灌损伤的线粒体机制 会议论文
52 Cardioprotection of intermittent hypoxia: regulation on Ca2+ homeostasis 会议论文
53 Intermittent hypoxia protects cardiomyocytes against I/R-induced alterations in Ca2+ homeostasis and contraction via the SR and Na+/Ca2+ exchange mechanisms. 期刊论文
54 A comparative study of pulmonary functional Imaging In Healthy Tibetan and Han youth Using Spiral CT Technique. 会议论文
55 Overexpression of heat dhock protein 27 against ischemia/reperfusion-induced cardiac contractile dysfunction via stabilization of troponin I and troponin T. 期刊论文
56 Comparative study of pulmonary arterial pressure in healthy children at different altitude by doppler echocardiography. 会议论文
57 低氧对心血管功能的影响及其机制. 专著
58 Primary screening for hypoxia-related genes. 会议论文
59 Urine acid-base compensation at simulated moderate altitude. 期刊论文
60 Biological roles and regulatory mechanisms of transcription factor E2F6. 期刊论文
61 Molecular cloning and characterization of hemoglobin alpha and beta chains from plateau pika (Ochotona curzoniae) living at high altitude. 期刊论文
62 常氧和急性低氧下大鼠传导性肺动脉平滑肌细胞的电生理特性 期刊论文 胡颖;邹飞;蔡春青;吴航宇;韵海霞;陈云天;靳国恩;格日力
63 藏羚羊大脑皮层cDNA文库的构建 期刊论文
64 青海省科学技术进步奖 奖励 赵晨星;黄鹤鸣;赵维纳;段新文;高定国;多旦;赵德先;裴正华;尕藏本;才华
65 A mitochondrial genome sequence of the Tibetan antelope (Pantholops hodgsonii). 期刊论文
66 Intermittent high altitude hypoxia inhibits opening of mitochondrial permeability transition pores against reperfusion injury. 期刊论文
67 E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1. 期刊论文
68 RNA干扰沉默低氧诱导因子-1α对低氧下大鼠肺动脉平滑肌细胞增殖的影响 期刊论文 张伟;曹越;张昱;马祁生;马兰;格日力
69 Measurement of the ventricular wall of children with high-altitude heart disease using magnetic resonance imaging. 会议论文
70 Hif-1 in different organs of human fetus at high altitude. 会议论文
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